单氯更昔洛韦缩合物的合成  

Synthesis of Monochloroganciclovir Condensate

作　　者：李鸣海 闫煜 陈正军 Li Minghai;Yan Yu;Chen Zhengjun(Shanghai Pharma Group(Changzhou)Kony Pharmaceutical Co.,Ltd.,Changzhou 213105 China)

机构地区：[1]上药康丽(常州)药业有限公司,江苏常州213105

出　　处：《云南化工》2024年第10期95-99,127,共6页Yunnan Chemical Technology

摘　　要：介绍以环氧氯丙烷为起始原料合成1-乙酰氧基-2-(酰氧基甲氧基)-3-氯丙烷,然后与二乙酰鸟嘌呤发生缩合反应得到单氯更昔洛韦缩合物。通过HPLC、^(1)H NMR和LC-MS等手段表征,分别对产品进行结构确证和纯度检测,结果表明,反应条件温和,制备的产品纯度高,可作为更昔洛韦原料药质量控制的杂质对照品。In this paper,1-acetoxy-2-(acyloxymethoxy)-3-chloropropane was synthesized with epichlorohydrin as the starting material,and then condensed with diacetylguanine to obtain monocloganciclovir condensate.The structure was confirmed and the purity was detected by HPLC,^(1)H NMR and LC-MS.The results showed that the reaction conditions were mild and the purity of the prepared impurities was high,which could be used as the impurity reference substance for the quality control of ganciclovir.

关 键 词：更昔洛韦 单氯更昔洛韦 环氧氯丙烷 杂质 合成 

分 类 号：TQ463[化学工程—制药化工]