基于改良UPOINT(S)系统的个体化治疗对CP/CPPS合并SD患者的疗效分析  

Curative effect analysis of individualized treatment based on UPOINT(S)phenotype classification system in chronic prostatitis/chronic pelvic pain syndrome combined with sexual dysfunction patients

作　　者：徐柳汀 张斌 苗鹏程 康印东 吴悠悠 常德辉 XU Liuting;ZHANG Bin;MIAO Pengcheng;KANG Yindong;WU Youyou;CHANG Dehui(Department of Urology,the 940th Hospital of Joint Logistics Support Force of Chinese People′s Liberation Army,Lanzhou 730050,Gansu,China;Department of Endocrinology,the 940th Hospital of Joint Logistics Support Force of Chinese People′s Liberation Army,Lanzhou 730050,Gansu,China)

机构地区：[1]中国人民解放军联勤保障部队第九四〇医院泌尿外科/全军泌尿外科中心,兰州730050 [2]中国人民解放军联勤保障部队第九四〇医院内分泌科,兰州730050

出　　处：《中国性科学》2024年第10期14-19,共6页Chinese Journal of Human Sexuality

基　　金：军队保健专项科研课题(21BJZ43);军队计生专项科研课题(21JSZ13);940医院院内专项培育项目(2021yxky017);甘肃省自然科学基金项目(22JR5RA001)。

摘　　要：目的基于改良UPOINT(S)临床表现分型系统,对慢性前列腺炎/慢性盆腔疼痛综合征(CP/CPPS)合并以勃起功能障碍(ED)、早泄(PE)为代表的性功能障碍(SD)患者采用以临床症状为导向的标准化诊断和个体化治疗,验证其临床疗效,并为选择临床治疗方案提供依据。方法选取2018年1月至2021年12月中国人民解放军联勤保障部队第九四○医院门诊治疗的160例CP/CPPS合并以ED和/或PE为代表的SD患者作为研究对象,随机分为常规药物治疗的对照组(n=53)、基于传统UPOINT临床表现分型系统指导治疗的传统组(n=49)和基于改良UPOINT(S)临床表现分型系统指导治疗的改良组(n=58)。根据各组治疗前后美国国立卫生研究院慢性前列腺炎症状指数(NIH-CPSI)评分、最大尿流率(Qmax)、视觉模拟评分法(VAS)评分、国际勃起功能指数5(IIEF-5)评分、中国早泄患者性功能评分表(C-ISFPE)评分、前列腺液中白细胞(EPS-WBC)计数的变化,评价三组临床疗效差异。结果治疗前三组临床资料差异均无统计学意义(P>0.05)。治疗后,与对照组比较,传统组和改良组在所有指标上均改善显著,差异均具有统计学意义(P<0.05);与传统组比较,改良组在治疗ED[IIEF-5评分(22.0±1.2)分vs.(19.8±2.0)分,P=0.006]和PE[C-ISFPE评分(25.5±1.8)分vs.(19.5±2.2)分,P=0.005]方面改善更加显著,差异均具有统计学意义(P<0.05)。结论基于改良UPOINT(S)临床表现分型系统指导的个体化治疗,可显著改善CP/CPPS合并SD患者的性功能异常状况,相较于常规治疗和基于传统UPOINT临床表现分型系统指导治疗的疗效更好。Objective To verify the clinical efficacy of chronic prostatitis/chronic pelvic pain syndrome(CP/CPPS)patients combined with sexual dysfunction(SD)represented by erectile dysfunction(ED)and/or premature ejaculation(PE)receiving clinical symptom-oriented standardized diagnosis and individualized treatment based on the UPOINT(S)phenotype classification system,and to provide a basis for selecting clinical treatment options.Methods A total of 160 CP/CPPS patients combined with SD represented by ED and/or PE in outpatient clinics of the 940th Hospital of Joint Logistics Support Force of Chinese People′s Liberation Army from January 2018 to December 2021 were selected as study objects and randomly divided into a control group for conventional drug therapy(n=53),a traditional group with guided treatment based on the traditional UPOINT phenotype classification system(n=49),an improvement group with guided treatment based on the improved UPOINT(S)phenotype classification system(n=58).According to the changes in National Institutes of Health chronic prostatitis symptom index(NIH-CPSI),maximum urinary flow rate(Qmax),visual analogue scale(VAS),international index of erectile function-5(IIEF-5),Chinese index of sexual function for premature ejaculation(C-ISFPE),and expressed prostatic secretion white blood cell count(EPS-WBC)before and after treatment,the differences in clinical efficacy between the three groups were evaluated.Results There was no statistical difference in clinical data in three groups of treatment(P>0.05).After treatment,the traditional group and the improvement group improved in all indicators compared with the control group,with statistical differences(P<0.05);compared with the traditional group,the improvement group improved more significantly in treatment of ED(IIEF-5 score:22.0±1.2 vs.19.8±2.0,P=0.006)and PE(C-ISFPE score:25.5±1.8 vs.19.5±2.2,P=0.005),with statistically significant differences(P<0.05).Conclusions Individualized treatment based on the UPOINT(S)phenotype classification system can s

关 键 词：慢性前列腺炎/慢性盆腔疼痛综合征 性功能障碍 改良UPOINT(S)临床表现分型系统 UPOINT临床表现分型系统 生物电反馈 低频脉冲电刺激 疗效 

分 类 号：R691[医药卫生—泌尿科学]