甘油三酯水平异常与非梗阻性无精子症发病风险的关联性研究  

A study on the correlation between abnormal levels of triglycerides and the morbidity risk of nonobstructive azoospermia

作　　者：胡悦 李晓超[2] HU Yue;LI Xiaochao(Department of Reproductive Medicine,Qinhuangdao First Hospital,Qinhuangdao 066000,Hebei,China;Department of Pathology,Qinhuangdao First Hospital,Qinhuangdao 066000,Hebei,China)

机构地区：[1]秦皇岛市第一医院生殖医学科,河北秦皇岛066000 [2]秦皇岛市第一医院病理科,河北秦皇岛066000

出　　处：《中国性科学》2024年第10期23-26,共4页Chinese Journal of Human Sexuality

基　　金：河北省医学科学研究重点课题计划项目(20240739)。

摘　　要：目的探讨甘油三酯(TG)水平异常与非梗阻性无精子症(NOA)发病风险的关联性。方法回顾性分析2020年9月至2023年9月秦皇岛市第一医院收治的119例NOA患者的临床资料作为研究组,选取同期119名已生育的健康男性的体检资料作为对照组。根据TG水平将两组分为TG异常组(n=138)与TG正常组(n=100)。采用限制性立方样条模型(RCS)分析TG水平与NOA发病风险间的剂量反应关系;采用Logistic回归分析NOA发病的影响因素;采用Pearson法分析TG与性激素的相关性。结果TG异常组NOA发生率为57.25%(79/138),高于TG正常组的40.00%(40/100),差异具有统计学意义(χ^(2)=6.899,P=0.009)。TG异常组体重指数(BMI)≥28.0 kg/m^(2)占比高于TG正常组,睾酮水平低于TG正常组,差异具有统计学意义(P<0.05)。Logistic回归分析显示,TG异常升高与NOA发病风险有关[OR(95%CI):2.008(1.190~3.389),P=2.008];调整混杂因素(BMI、睾酮)后,TG异常升高仍与NOA发病风险有关[OR(95%CI):1.780(1.025~3.089),P=0.040]。RCS分析显示,TG水平与NOA发病风险的关联呈非线性曲线型剂量反应关系,当TG水平异常升高时,NOA发病风险也随之升高。Pearson相关性分析显示,TG与睾酮呈负相关(r=-0.139,P=0.032),与卵泡刺激素(FSH)呈正相关(r=0.179,P=0.006)。结论TG异常与NOA的发生相关,TG水平越高则NOA患病风险越高,临床可考虑控制TG水平以预防NOA发生。Objective To investigate the correlation between abnormal levels of triglycerides(TG)and the morbidity risk of non-obstructive azoospermia(NOA).Methods The clinical levels of data of 119 NOA patients admitted to Qinhuangdao First Hospital from September 2020 to September 2023 were retrospectively analyzed and set as the research group,and the physical examination data of 119 healthy men who had given birth during the same period were selected as the control group.According to the levels of TG,the two groups were divided into TG abnormal group(n=138)and TG normal group(n=100).The association between TG levels and the morbidity risk of NOA was analyzed by restricted cubic spline(RCS).Logistic regression was conducted to analyze the influencing factors of NOA morbidity.Pearson method was conducted to analyze the correlation between TG and sexual hormones.Results The incidence of NOA in TG abnormal group was 57.25%(79/138),which was higher than 40.00%(40/100)in TG normal group,with a statistically significant difference(χ^(2)=6.899,P=0.009).The proportion of body mass index(BMI)≥28.0 kg/m^(2) in TG abnormal group was higher than that in TG normal group,and the level of testosterone was lower than that in TG normal group,with statistical significances(P<0.05).Logistic regression analysis showed that abnormally elevated TG was associated with the risk of NOA[OR(95%CI):2.008(1.190-3.389),P=2.008].After adjusting for confounding factors(BMI and testosterone),abnormal elevation of TG was still associated with the risk of NOA[OR(95%CI):1.780(1.025-3.089),P=0.040].The RCS analysis showed a non-linear dose-response relationship between TG levels and the morbidity risk of NOA.When TG levels abnormally increased,the morbidity risk of NOA also increased.Pearson correlation analysis showed that TG was negatively correlated with testosterone(r=-0.139,P=0.032)and positively correlated with follicle stimulating hormone(FSH)(r=0.179,P=0.006).Conclusions Abnormal TG levels are associated with the occurrence of NOA.The higher the T

关 键 词：非梗阻性无精子症 甘油三酯 男性不育 

分 类 号：R697[医药卫生—泌尿科学]