子宫内膜癌组织中ZEB2和IGF1R表达情况及其与患者淋巴结转移及预后的关系  

Expression of E-box binding zinc finger protein 2 and insulin like growth factor-1 receptor in endometrial carcinoma and their relationship with lymph node metastasis and prognosis

作　　者：焦英亚 李宾[2] 韩飞飞 JIAO Yingya;LI Bin;HAN Feifei(Department of Operating Room,Handan Central Hospital,Handan 056001,Hebei,China;Department of Gynecology,Handan Central Hospital,Handan 056001,Hebei,China)

机构地区：[1]邯郸市中心医院手术室,河北邯郸056001 [2]邯郸市中心医院妇科,河北邯郸056001

出　　处：《中国性科学》2024年第10期87-91,共5页Chinese Journal of Human Sexuality

基　　金：2023年度河北省医学科学研究课题(20230248)。

摘　　要：目的探讨E盒结合锌指蛋白2(ZEB2)和胰岛素样生长因子1受体(IGF1R)在子宫内膜癌组织中的表达情况及其与淋巴结转移及预后的关系。方法选取2018年6月至2020年6月邯郸市中心医院收治的137例行手术治疗的子宫内膜癌患者作为研究对象,收集患者在手术过程中切除的癌组织及癌旁组织。采用免疫组化方法检测组织中ZEB2和IGF1R的表达情况,进一步分析患者的病理特征与ZEB2和IGF1R表达情况的关系及不同临床特征与淋巴结转移的关系。进行定期随访,根据随访结果采用Kaplan-Meier法分析患者预后生存情况,采用Cox回归模型进行患者预后不良的多因素分析。结果子宫内膜癌组织中ZEB2和IGF1R阳性表达率均高于癌旁组织(P<0.05)。子宫内膜癌组织中ZEB2和IGF1R表达水平与与国际妇产科联盟(FIGO)分期、淋巴结是否转移有关(P<0.05)。淋巴结转移情况与肿瘤直径、FIGO分期有关(P<0.05)。子宫内膜癌组织ZEB2阳性表达患者3年生存率低于ZEB2阴性表达患者(P<0.05),子宫内膜癌组织IGF1R阳性表达患者3年生存率低于IGF1R阴性表达患者(P<0.05)。FIGO分期、淋巴结转移、ZEB2和IGF1R阳性表达均为子宫内膜癌患者预后不良的影响因素(P<0.05)。结论与癌旁组织比较,子宫内膜癌组织中ZEB2和IGF1R阳性表达率较高,且与患者的FIGO分期、淋巴结转移情况有关。Objective To investigate the expression of E-box binding zinc finger protein 2(ZEB2)and insulin-like growth factor-1 receptor(IGF1R)in endometrial carcinoma and its relationship with lymph node metastasis and prognosis.Methods A total of 137 patients with endometrial cancer who underwent surgical treatment in Handan Central Hospital from June 2018 to June 2020 were selected as the study objects,and the cancer tissues and paracancer tissues removed during surgery were collected.Immunohistochemical methods were used to detect the expression of ZEB2 and IGF1R in tissues,the relationship between the pathological features of patients and the expression of ZEB2 and IGF1R,and the relationship between different clinical features and lymph node metastasis were further analyzed.Regular follow-up was conducted,and Kaplan-Meier method was used to analyze the prognosis and survival of patients according to the follow-up results.Multivariate analysis of poor prognosis was performed by Cox regression model.Results The positive expression rates of ZEB2 and IGF1R in endometrial carcinoma tissues were higher than those in paracancer tissues(P<0.05).The expression levels of ZEB2 and IGF1R in endometrial carcinoma were correlated with international federation of gynecology and obstetrics(FIGO)staging and lymph node metastasis(P<0.05).Lymph node metastasis status was correlated with tumor diameter and FIGO stage(P<0.05).The 3-year survival rate of patients with positive expression of ZEB2 in endometrial cancer tissue was lower than that of patients with negative expression of ZEB2(P<0.05),and the 3-year survival rate of patients with positive expression of IGF1R in endometrial cancer tissue was lower than that of patients with negative expression of IGF1R(P<0.05).FIGO stage,lymph node metastasis,ZEB2 and IGF1R positive expression were all factors influencing poor prognosis of endometrial carcinoma patients(P<0.05).Conclusions The positive expression rates of ZEB2 and IGF1R in endometrial carcinoma tissues were higher than those in pa

关 键 词：子宫内膜癌 E盒结合锌指蛋白2 胰岛素样生长因子1受体 淋巴结转移 

分 类 号：R711[医药卫生—妇产科学]