李曰庆教授治疗慢性前列腺炎组方分析及核心处方网络药理学研究  

Analysis of Professor Li Yueqing′s prescription for chronic prostatitis and network pharmacology study of core prescription

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作  者:彭爱进 王继升[1] 赵琦 赵聪 黄念文 王世桢 徐洪胜 王彬[1] PENG Aijin;WANG Jisheng;ZHAO Qi;ZHAO Cong;HUANG Nianwen;WANG Shizhen;XU Hongsheng;WANG Bin(Department of Andrology,Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 100700,China;Department of Urology,Nantong Hospital of Traditional Chinese Medicine,Nantong 226001,Jiangsu,China)

机构地区:[1]北京中医药大学东直门医院男科,北京100700 [2]南通市中医院泌尿外科,江苏南通226001

出  处:《中国性科学》2024年第10期112-117,共6页Chinese Journal of Human Sexuality

基  金:国家重点研发计划“中医药现代化研究”(2018YFC1704100);中华中医药学会青年求实项目(2021-QNQS-03);首都卫生发展科研专项项目(2020-2-4191)。

摘  要:目的基于古今医案云平台挖掘李曰庆教授治疗慢性前列腺炎的中医用药规律,通过网络药理学研究核心处方治疗慢性前列腺炎的机制。方法筛选2020年6月至2022年12月北京中医药大学东直门医院李曰庆专家门诊诊治的慢性前列腺炎患者,获取其的处方用药并录入古今医案云平台,构建数据库,通过频次统计、关联规则分析、复杂网络分析等模块归纳李曰庆教授治疗慢性前列腺炎的组方规律,通过网络药理学探索核心处方的有效成分、靶点及信号通路。结果经数据筛选后共录入240首处方,涉及中药共350味,包含10味常用中药(频次>100次),10对关联规则(置信度≥0.9);核心处方由“白芍、甘草、川芎、茯苓、白芷、桂枝、黄芪、延胡索”构成,共含有142个有效成分,共同靶点128个,蛋白激酶B(AKT1)、丝裂原活化蛋白激酶1(MAPK1)、肿瘤坏死因子(TNF)、白介素-6(IL-6)等为关键靶点,晚期糖基化终产物及其受体(AGE-RAGE)等为关键信号通路。结论李曰庆教授治疗慢性前列腺炎用药灵活,总体遵循“扶正祛邪,恢复机体功能”的治疗原则,温法与清法同用,重视活血化瘀。核心处方可能通过癌症通路、AGE-RAGE、脂质与动脉粥样硬化等相关通路治疗慢性前列腺炎。Objective To excavate the traditional Chinese medicine(TCM)medication rule of Professor Li Yueqing in the treatment of chronic prostatitis(CP)based on ancient and modern medical records cloud platform,and to study the mechanism of core prescription in the treatment of CP by network pharmacology.Methods CP patients who were treated in the expert clinic of Li Yueqing in Dongzhimen Hospital,Beijing University of Chinese Medicine from June 2020 to December 2022 were screened,and the prescription drugs were obtained and recorded into ancient and modern medical records cloud platform,and the database was constructed.The prescription rules of Professor Li Yueqing in the treatment of CP were summarized by using the modules of frequency statistics,association rule analysis and complex network analysis.The effective components,targets and signal pathways of the core prescription were explored by the network pharmacology.Results After data screening,a total of 240 prescriptions were recorded,involving 350 TCMs,including 10 commonly used TCMs(frequency>100)and 10 pairs of association rules(confidence coefficient≥0.9).The core prescription was composed of"radix paeoniae alba,glycyrrhiza uralensis,ligusticum chuanxiong,poria cocos,angelica dahurica,cassia twig,radix astragali,rhizoma corydalis",which contained 142 active ingredients and 128 common targets.Serine-threonine protein kinase 1(AKT1),mitogen activated protein kinase 1(MAPK1),tumor necrosis factor(TNF)and interleukin-6(IL-6)were the key targets,and advanced glycation end product(AGE)-receptor for AGE(RAGE)was the key signal pathway.Conclusions Professor Li Yueqing is flexible in the treatment of CP,generally following the treatment principle of"invigorating the positive and dispelling evil,restoring the function of the body",using both warming method and clearing method together,and paying attention to promoting blood circulation and removing blood stasis.The core prescription may treat chronic prostatitis through cancer pathway,AGE-RAGE,lipid and atherosclerosis a

关 键 词:慢性前列腺炎 古今医案云 李曰庆 组方规律 网络药理学 

分 类 号:R275[医药卫生—中医皮科]

 

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