复方斑蝥胶囊联合放疗治疗前列腺癌骨转移患者的疗效  

The efficacy of compound cantharidin capsule combined with radiotherapy in the treatment of prostate cancer patients with bone metastasis

作　　者：江帆 赵洁 齐雯洁 刘梦婷 张伟通 闫丽娟 JIANG Fan;ZHAO Jie;QI Wenjie;LIU Mengting;ZHANG Weitong;YAN Lijuan(Tumor Diagnosis and Treatment Center,Baoji Gaoxin Hospital,Baoji 721000,Shaanxi,China)

机构地区：[1]宝鸡高新医院肿瘤诊疗中心,陕西宝鸡721000

出　　处：《中国性科学》2024年第10期125-129,共5页Chinese Journal of Human Sexuality

摘　　要：目的观察复方斑蝥胶囊联合放疗治疗前列腺癌(PCa)骨转移(BM)患者的疗效。方法选取2022年1月至2023年3月宝鸡高新医院肿瘤诊疗中心收治的92例PCa BM患者作为研究对象。采用随机数字表法分为对照组和研究组,每组46例。对照组进行放疗,研究组在对照组基础上联合复方斑蝥胶囊治疗。比较两组疗效、视觉模拟评分法(VAS)评分、免疫指标、不良骨事件发生情况,比较两组血清碱性磷酸酶(ALP)、前列腺特异性抗原(PSA)、血管内皮生长因子(VEGF)、前梯度蛋白2(AGR2)水平。结果研究组总有效率高于对照组(P<0.05)。治疗后,两组的血清PSA、VEGF、AGR2水平及VAS评分均小于治疗前,且研究组小于对照组,差异具有统计学意义(P<0.05)。治疗后,两组的血清ALP水平均大于治疗前,且研究组小于对照组,差异具有统计学意义(P<0.05)。治疗后,两组的CD4^(+)/CD8^(+)、CD4^(+)、CD3^(+)、IgA、IgM均小于治疗前,且研究组大于对照组,差异具有统计学意义(P<0.05)。研究组不良骨事件总发生率低于对照组(P<0.05)。结论复方斑蝥胶囊联合放疗治疗PCa BM患者的疗效较好,能缓解疼痛,改善骨代谢和免疫能力,安全性较好。Objective To observe the efficacy of compound cantharidin capsule combined with radiotherapy in the treatment of prostate cancer(PCa)patients with bone metastasis(BM).Methods A total of 92 PCa BM patients who treated in Tumor Diagnosis and Treatment Center,Baoji Gaoxin Hospital from January 2022 to March 2023 were selected as study objects.They were divided into control group and study group by the random number table method,with 46 cases in each group.The control group received radiotherapy,while the study group received compound cantharidin capsule based on control group.The curative effect,visual analogue scale(VAS)score,immune indicators,and adverse bone events were compared between the two groups,and the levels of serum alkaline phosphatase(ALP),prostate specific antigen(PSA),vascular endothelial growth factor(VEGF),and anterior gradient 2(AGR2)were compared between the two groups.Results Study group had a higher total effective rate than control group(P<0.05).After treatment,the serum PSA,VEGF,AGR2 levels,and VAS score of both groups were lower than those before treatment(P<0.05),and those in study group were lower than control group(P<0.05).After treatment,the serum ALP level in both groups was higher than before treatment(P<0.05),and that in study group was lower than control group(P<0.05).After treatment,the CD4+/CD8+,CD4+,CD3+,IgA,and IgM in both groups were lower than those before treatment(P<0.05),and those in study group were higher than control group(P<0.05).Study group had a lower total incidence of adverse bone events than control group(P<0.05).Conclusions The combination of compound cantharidin capsule and radiotherapy has a good therapeutic effect on PCa BM patients,which can alleviate pain,improve bone metabolism and immune function,and has good safety.

关 键 词：复方斑蝥胶囊 放疗 前列腺癌 骨转移 疗效 血管内皮生长因子 前梯度蛋白2 

分 类 号：R697[医药卫生—泌尿科学]