《证治准绳·女科·积聚癥瘕》组方用药规律研究  

The prescription and medication rule of Ji Ju and Zheng Jia in Nyu Ke in Zheng Zhi Zhun Sheng

作　　者：王润涵 刘洋 王欣 师伟[2] WANG Runhan;LIU Yang;WANG Xin;SHI Wei(Master Degree Candidate of Traditional Chinese Gynecology Enrolled in 2023,the First School of Clinical Medicine,Shandong University of Traditional Chinese Medicine,Jinan 250014,Shandong,China;Master Degree Candidate of Traditional Chinese Gynecology Enrolled in 2021,the First School of Clinical Medicine,Shandong University of Traditional Chinese Medicine,Jinan 250014,Shandong,China;Master Degree Candidate of Traditional Chinese Gynecology Enrolled in 2022,the First School of Clinical Medicine,Shandong University of Traditional Chinese Medicine,Jinan 250014,Shandong,China;Department of Gynecology,Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250014,Shandong,China)

机构地区：[1]山东中医药大学第一临床医学院,济南250014 [2]山东中医药大学附属医院妇科,济南250014

出　　处：《中国性科学》2024年第10期132-136,共5页Chinese Journal of Human Sexuality

基　　金：国家自然科学基金面上项目(81873330);泰山学者青年专家项目(No.tsqn201909185)。

摘　　要：目的分析《证治准绳·女科·积聚癥瘕》组方用药规律。方法整理《证治准绳·女科·积聚癥瘕》一篇中收录的医案处方及附方,采用Excel 2016统计符合筛选标准的方剂,采用SPSS Modeler 18.1和SPSS Statistics 28.0进行关联规则分析和聚类分析。结果共录入66首方剂,涉及118味中药。频次≥5的高频药物共28味,前2位分别为当归、大黄;药物按功效分为22类,前2位分别为活血化瘀药、补虚药。药性以温为主,药味以辛、苦、甘居多,药物归经多集中于肝经、脾经。通过关联规则分析得出三棱与莪术、肉桂与莪术等15条药物关联规则。聚类分析得出3类药物组合。结论《证治准绳·女科·积聚癥瘕》组方用药规律为以血为主,破血消癥;养正除积,固本宜缓;审证散瘀,温主寒辅。Objective To analyze the rules of prescription and medication of Ji Ju and Zheng Jia in Nyu Ke in Zheng Zhi Zhun Sheng.Methods The medical prescriptions and supplementary prescriptions included in Ji Ju and Zheng Jia in Nyu Ke in Zheng Zhi Zhun Sheng were sorted.Excel 2016 was used to count the prescriptions met the screening criteria,and SPSS Modeler 18.1 and SPSS Statistics 28.0 were used for the association rule analysis and cluster analysis.Results A total of 66 prescriptions were documented,involving 118 traditional Chinese herbal medicine.There were 28 high-frequency drugs occurring more than five times,with angelica sinensis and rhubarb being the two most frequently used drugs.The drugs were categorized into 22 groups based on their therapeutic effects,with the top two categories being the blood-activating and stasis-removing drugs as well as tonifying drugs.The nature of the medications is primarily warm,and the flavors are predominantly pungent,bitter and sweet.The meridian tropism of drugs mainly concentrated in the liver and spleen meridians.Through association rule analysis,15 drug association rules were obtained,such as rhizoma sparganii and rhizoma curcumae or cinnamon and rhizoma curcumae.Additionally,cluster analysis yielded three combinations of drugs.Conclusions The prescription and medication rules of Ji Ju and Zheng Jia in Nyu Ke in Zheng Zhi Zhun Sheng are as follows:attaching great importance to blood,promoting blood circulation,removing blood stasis,cultivating Zheng and eliminating Jia,gradually enhancing the healthy of the human body and eliminating diseases that have accumulated in the body for a long time.Syndrome differentiation focuses on resolving blood stasis,primarily emphasizing the utilization of warm-natured drugs while complementarily incorporating cold-natured drugs.

关 键 词：《证治准绳·女科》 积聚癥瘕 组方用药规律 数据挖掘 王肯堂 

分 类 号：R271[医药卫生—中医妇科学]