老年重症心力衰竭急诊内科治疗的临床效果分析  

Analysis of clinical effect of emergency medical treatment of severe heart failure in the elderly

作　　者：许静 XU Jing(Jinan Seventh People's Hospital,Jinan 250000,China)

机构地区：[1]济南市第七人民医院,250000

出　　处：《中国现代药物应用》2024年第19期82-85,共4页Chinese Journal of Modern Drug Application

摘　　要：目的探讨老年重症心力衰竭急诊内科治疗的临床效果。方法选取106例老年重症心力衰竭患者,通过电脑随机分为实验组和对照组,每组53例。两组患者均进行常规内科治疗,对照组患者在常规内科治疗基础上给予美托洛尔治疗,实验组患者在对照组基础上联合厄贝沙坦氢氯噻嗪治疗。比较两组患者心功能指标[左心室射血分数(LVEF)、心排血量(CO)、B型脑钠肽(BNP)、心型脂肪酸结合蛋白(hFABP)]及临床疗效。结果治疗后,实验组患者LVEF为(45.68±4.02)%、CO为(4.23±0.38)L/min,对照组患者LVEF为(39.25±4.15)%、CO为(3.52±0.42)L/min。两组患者治疗后LVEF、CO均较治疗前有所升高,且实验组患者LVEF、CO均明显高于对照组(P<0.05)。治疗后,实验组患者BNP为(721.67±90.78)pg/ml、hFABP为(10.72±2.57)ng/L,对照组患者BNP为(895.61±101.53)pg/ml、hFABP为(13.61±3.21)ng/L。两组患者治疗后BNP、hFABP均较治疗前有所下降,且实验组患者BNP、hFABP均明显低于对照组(P<0.05)。实验组总有效率(94.3%)显著高于对照组(69.8%)(P<0.05)。结论老年重症心力衰竭患者接受美托洛尔联合厄贝沙坦氢氯噻嗪治疗,能显著改善患者心功能,提高生命质量,具有临床推广价值。Objective To explore the clinical effect of emergency medical treatment of severe heart failure in the elderly.Methods A total of 106 elderly patients with severe heart failure were randomly divided into an experimental group and a control group,with 53 cases in each group.Patients in both groups received conventional medical treatment,on this basis,the control group received metoprolol,and experimental group received irbesartan and hydrochlorothiazide on the basis of the control group.Comparison was made on cardiac function indexes[left ventricular ejection fraction(LVEF),cardiac output(CO),B-type natriuretic peptide(BNP),heart fatty acid-binding protein(hFABP)]and clinical efficacy between the two groups.Results After treatment,LVEF and CO of the experimental group were(45.68±4.02)%and(4.23±0.38)L/min,and those of the control group were(39.25±4.15)%and(3.52±0.42)L/min.After treatment,LVEF and CO in both groups were higher than those before treatment,and LVEF and CO in the experimental group were significantly higher than those in the control group(P<0.05).After treatment,BNP and hFABP of the experimental group were(721.67±90.78)pg/ml and(10.72±2.57)ng/L,and those of the control group were(895.61±101.53)pg/ml and(13.61±3.21)ng/L.After treatment,BNP and hFABP in both groups were significantly decreased compared with those before treatment,and BNP and hFABP in the experimental group were significantly lower than those in the control group(P<0.05).The total effective rate of the experimental group(94.3%)was significantly higher than that of the control group(69.8%)(P<0.05).Conclusion Metoprolol combined with irbesartan and hydrochlorothiazide can significantly improve cardiac function and quality of life in elderly patients with severe heart failure,and has clinical value.

关 键 词：老年重症心力衰竭 急诊内科 美托洛尔 厄贝沙坦氢氯噻嗪 

分 类 号：R541.6[医药卫生—心血管疾病]