甲巯咪唑联合阿卡波糖、甘精胰岛素对甲状腺功能亢进伴糖尿病患者血糖调控及甲状腺激素水平的影响  

Effects of Methimazole Combined with Acarbose and Insulin Glargine on Blood Glucose Regulation and Thyroid Stimulating Level in Patients with Hyperthyroidism and Diabetes Mellitus

作　　者：刁亚丽 DIAO Yali(Department of Endocrinology,Yanggu County People's Hospital,Liaocheng 252300,Shandong,China)

机构地区：[1]阳谷县人民医院内分泌科,山东聊城252300

出　　处：《糖尿病新世界》2024年第14期65-68,共4页Diabetes New World

摘　　要：目的 探究甲巯咪唑联合阿卡波糖、甘精胰岛素对甲状腺功能亢进(简称甲亢)伴糖尿病患者血糖调控及甲状腺激素水平的影响。方法 选取2022年1月—2023年11月阳谷县人民医院收治的96例甲亢伴糖尿病患者为研究对象,依据治疗方式不同将其分为A组(接受阿卡波糖+甲巯咪唑治疗)、B组(接受阿卡波糖+甲巯咪唑+甘精胰岛素治疗),各48例。比较两组治疗效果、血糖水平、胰岛β细胞功能指数、胰岛素抵抗指数、血糖达标时间、甲状腺激素水平及不良反应发生率。结果 B组治疗总有效率高于A组,差异有统计学意义(P<0.05)。治疗后,B组空腹血糖、餐后2 h血糖、胰岛素抵抗指数、甲状腺素水平均低于A组,胰岛β细胞功能指数、促甲状腺激素水平高于A组,血糖达标时间短于A组,差异有统计学意义(P均<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论 甲亢伴糖尿病在甲巯咪唑治疗基础上联合阿卡波糖及甘精胰岛素,可提升治疗效果,改善其血糖及甲状腺激素水平,减轻患者胰岛素抵抗症状,缩短血糖达标时间,且治疗安全性良好。Objective To explore the effects of methimazole combined with acarbose and insulin glargine on blood glu-cose regulation and thyroid hormone levels in patients with hyperthyroidism and diabetes mellitus.Methods A total of 96 patients with hyperthyroidism and diabetes mellitus admitted to Yanggu County People's Hospital from January 2022 to November 2023 were selected as the research objects.According to different treatment methods,they were di-vided into group A(treated with acarbose+methimazole)and group B(treated with acarbose+methimazole+insulin glargine),with 48 cases in each group.The therapeutic effect,blood glucose levels,isletβcell function index,insulin resistance index,blood glucose compliance time,thyroid hormone levels and incidence of adverse reactions were com-pared between the two groups.Results The total effective rate of treatment in group B was higher than that in group A,and the difference was statistically significant(P<0.05).After treatment,the fasting plasma glucose,2-hour postpran-dial plasma glucose,insulin resistance index and thyroxine level were lower than those in group A,the isletβcell function index and thyrotropin level were higher than those in group A,and the blood glucose compliance time in group B was shorter than that in group A,and the differences were statistically significant(all P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Hyperthy-roidism with diabetes mellitus combined with acarbose and insulin glargine on the basis of methimazole treatment can improve the therapeutic effect,improve the blood glucose and thyroid hormone levels,reduce the symptoms of insulin resistance,shorten blood glucose complime time,and the treatment safety is good.

关 键 词：甲状腺功能亢进 糖尿病 甲巯咪唑 甘精胰岛素 

分 类 号：R587.1[医药卫生—内分泌]