应用持续血糖监测技术评估德谷胰岛素治疗1型糖尿病的效果  

Effect of Insulin Degludec in the Treatment of Type 1 Diabetes Mellitus by Continuous Blood Glucose Monitoring Technology

作　　者：张秀娟 ZHANG Xiujuan(Second Department of Internal Medicine,Zhangdian District Hospital of Traditional Chinese Medicine,Zibo 255000,)

机构地区：[1]淄博市张店区中医院内二科,山东淄博255000

出　　处：《糖尿病新世界》2024年第14期72-75,共4页Diabetes New World

摘　　要：目的 应用持续血糖监测(continuous blood glucose monitoring, CGM)评估德谷胰岛素治疗1型糖尿病的效果。方法 选取2023年3月—2024年3月淄博市张店区中医院收治的100例1型糖尿病患者为研究对象,以治疗方法的不同分为甘精组、德谷组,各50例。甘精组以甘精胰岛素治疗,德谷组以德谷胰岛素治疗。比较两组血糖指标、转归情况、治疗效果、不良反应发生情况。结果 治疗后,两组空腹血糖、餐后2 h血糖及糖化血红蛋白水平均低于治疗前,且德谷组低于甘精组,差异有统计学意义(P均<0.05)。德谷组平均血糖波动幅度、日间血糖平均绝对差、血糖标准差、平均血糖以及血糖变异系数低于甘精组,差异有统计学意义(P均<0.05)。德谷组治疗总有效率高于甘精组,差异有统计学意义(P<0.05)。德谷组不良反应发生率低于甘精组,差异有统计学意义(P<0.05)。结论 德谷胰岛素达到的血糖调控效果更为显著,能减少低血糖发生率,降低血糖变异系数,改善1型糖尿病预后。Objective To evaluate the effect of insulin degludec in the treatment of type 1 diabetes mellitus using con-tinuous blood glucose monitoring(CGM).Methods A total of 100 patients with type 1 diabetes mellitus admitted to Zhangdian District Hospital of Traditional Chinese Medicine of Zibo from March 2023 to March 2024 were selected as the research objects.According to different treatment methods,they were divided into glargine group and degludec group,with 50 cases in each group.The glargine group was treated with insulin glargine,and the degludec group was treated with insulin degludec.The blood glucose indexes,outcome,treatment effect and incidence of adverse reactions were compared between the two groups.Results After treatment,the levels of fasting plasma glucose,2-hour post-prandial plasma glucose and glycated hemoglobin A1c in the two groups were lower than those before treatment,and those in the degludec group were lower than those in the glargine group,and the differences were statistically signifi-cant(all P<0.05).The mean blood glucose fluctuation range,mean absolute difference of daytime blood glucose,stan-dard deviation of blood glucose,mean blood glucose and coefficient of variation of blood glucose in the degludec group were lower than those in the glargine group,and the differences were statistically significant(all P<0.05).The total ef-fective rate of treatment in the degludec group was higher than that of the glargine group,and the difference was statis-tically significant(P<0.05).The incidence of adverse reactions in the degludec group was lower than that in the glargine group,and the difference was statistically significant(P<0.05).Conclusion Insulin degludec has a more sig-nificant effect in blood glucose regulation,which can reduce the incidence of hypoglycemia,reduce the coefficient of variation of blood glucose,and improve the prognosis of type 1 diabetes mellitus.

关 键 词：1型糖尿病 德谷胰岛素 临床疗效 持续血糖监测技术 

分 类 号：R587.1[医药卫生—内分泌]