恩格列净辅助胰岛素短期强化治疗对老年2型糖尿病患者血糖波动及安全性的影响  

Effect of Short-term Intensive Treatment of Englaglitzin with Insulin on Blood Glucose Fluctuation and Safety in Elderly Patients with Type 2 Dia⁃betes Mellitus

作　　者：徐丹 房婷婷 范淑芳 XU Dan;FANG Tingting;FAN Shufang(Department of Pharmacy,Sanming First Hospital,Sanming 365000,Fujian,China)

机构地区：[1]三明市第一医院药剂科,福建三明365000

出　　处：《糖尿病新世界》2024年第14期98-101,共4页Diabetes New World

摘　　要：目的 探讨老年2型糖尿病(type 2 diabetes mellitus, T2DM)患者采用恩格列净及胰岛素短期强化治疗对血糖波动及安全性的影响。方法 选取2023年1—12月三明市第一医院收治的98例T2DM患者为研究对象,按治疗方法不同分组,每组49例。对照组采取胰岛素短期强化治疗,观察组在对照组基础上加用恩格列净治疗。比较两组胰岛功能、血糖指标、血糖波动、安全性。结果 治疗后,两组胰岛素抵抗指数、糖化血红蛋白、空腹血糖、餐后2 h血糖、餐后血糖波动幅度、血糖最大波动均低于治疗前,且观察组均低于对照组,差异有统计学意义(P均<0.05);治疗后,两组胰岛β细胞功能高于治疗前,且观察组均高于对照组,差异有统计学意义(P<0.05)。两组不良反应发生情况对比,差异无统计学意义(P>0.05)。结论 老年T2DM患者采用恩格列净及胰岛素短期强化治疗能够促进胰岛功能改善,调节血糖水平,减少血糖波动,且具有良好的安全性。Objective To investigate the effects of short-term intensive treatment with englaglizin and insulin on blood glucose fluctuation and safety in elderly patients with type 2 diabetes mellitus(T2DM).Methods A total of 98 T2DM patients admitted to the First Hospital of Sanming City from January to December 2023 were selected as the re-search objects and and they were divided into 49 cases in each group according to different treatment methods.The control group received short-term intensive insulin treatment,and the observation group was treated with englaglizin on the basis of control group.Islet function(islet beta cell function,insulin resistance index),blood glucose index,blood glucose fluctuation and safety were compared between the two groups.Results After treatment,homeostsis model assessment of insulin resistance,glycated hemoglobin A1c,fasting plasma glucose,2-hour postprandial plasma glucose,postprandial plasma glucose fluctuation amplitude amplitude and largest omplitude of ghycemic excursion in two groups were lower than before treatment,and observation group was lower than control group,the differences were statistically significant(all P<0.05).After treatment,the homeostasis model assessment ofβcell function index in the two groups was higher than before treatment,and the observation group was higher than the control group,the differ-ence was statistically significant(P<0.05).There was no significant difference in the occurrence of adverse reactions between the two groups(P>0.05).Conclusion Short-term intensive treatment with empagliflozin and insulin in elderly patients with T2DM can improve islet function,regulate blood glucose level,reduce blood glucose fluctuation,and has good safety.

关 键 词：2型糖尿病 恩格列净 胰岛素 血糖波动 胰岛功能 

分 类 号：R4[医药卫生—临床医学]