分析糖尿病周围神经病变患者联合使用木丹颗粒、依帕司他治疗对总体疗效及震动感觉阈值的影响  

Effects of Combined Treatment of Mudan Granule and Epalrestat on the Overall Curative Effect and Vibration Perception Threshold in Diabetic Peripheral Neuropathy Patients

作　　者：房丛丛 钱鑫 刘新芸 FANG Congcong;QIAN Xin;LIU Xinyun(Department of Endocrinology,Jinan First People's Hospital,Jinan 250000,Shandong,China;Department of Respi-ratory Medicine,Jinan First People's Hospital,Jinan 250000,Shandong,China;Department of Neurology,Jinan First People's Hospital,Jinan 250000,Shandong,China)

机构地区：[1]济南市第一人民医院内分泌科,山东济南250000 [2]济南市第一人民医院呼吸内科,山东济南250000 [3]济南市第一人民医院神经内科,山东济南250000

出　　处：《糖尿病新世界》2024年第14期168-171,193,共5页Diabetes New World

摘　　要：目的 探讨糖尿病周围神经病变(diabetic peripheral neuropathy, DPN)患者联合使用木丹颗粒、依帕司他治疗对总体疗效及震动感觉阈值(vibration perception threshold, VPT)的影响。方法 选取2023年2月—2024年4月济南市第一人民医院收治的120例DPN患者为研究对象,按治疗方法不同分为木丹颗粒组(以木丹颗粒治疗)、依帕司他组(以依帕司他治疗)及联合组(以木丹颗粒与依帕司他联合治疗),每组40例。比较3组治疗总有效率、不良反应发生情况、VPT指标水平、中医证候积分。结果 木丹颗粒组与依帕司他组治疗总有效率对比,差异无统计学意义(P>0.05)。联合组治疗总有效率高于木丹颗粒组与依帕司他组,差异有统计学意义(P均<0.05)。木丹颗粒组不良反应发生率最低,但与依帕司他组与联合组对比,差异无统计学意义(P均>0.05)。治疗后,联合组左侧足底、右侧足底VPT指标水平均低于木丹颗粒组与依帕司他组,差异有统计学意义(P均<0.05);木丹颗粒组与依帕司他组各项VPT指标水平对比,差异无统计学意义(P均>0.05)。治疗后,联合组四肢乏力、四肢麻木、四肢疼痛积分均低于木丹颗粒组与依帕司他组,差异有统计学意义(P均<0.05);木丹颗粒组与依帕司他组各项中医证候积分对比,差异无统计学意义(P均>0.05)。结论 DPN患者联合应用木丹颗粒和依帕司他能够有效改善症状表现和VPT指标水平,且改善作用优于单一药物治疗,安全性较高。Objective To investigate the effects of combined treatment of Mudan Granule and epalrestat on the overall efficacy and vibration perception threshold(VPT)in patients with diabetic peripheral neuropathy(DPN).Methods A total of 120 DPN patients admitted to Jinan First People's Hospital from February 2023 to April 2024 were selected as the study objects,and were divided into Mudan Granule group(treated with Mudan Granule),epalrestat group(treated with epalrestat)and combined group(treated with Mudan Granule and epalrestat)according to different treatment methods,with 40 cases in each group.The total effective rate,adverse reactions,VPT index level and traditional Chi-nese medicine syndrome score of 3 groups were compared.Results There was no significant difference in the total ef-fective rate between Mudan Granule group and epalrestat group(P>0.05).The total effective rate of the combined group were higher than those of the Mudan Granule group and the epalrestat group,and the differences were statisti-cally significant(both P<0.05).Mudan Granule group had the lowest incidence of adverse reactions,but there were no significant differences compared with the epalrestat group and combined group(all P>0.05).After treatment,the VPT index levels of the left and right plantar of the combined group were lower than those of the Mudan Granule group and the epalrestat group,and the differences were statistically significant(all P<0.05).There was no significant difference in VPT between Mudan Granule group and epalrestat group(all P>0.05).After treatment,the scores of limb weakness,limb numbness and limb pain in the combined group were lower than those in the Mudan Granule group and the epalr-estat group,and the differences were statistically significant(all P<0.05).There was no significant difference in tradi-tional Chinese medicine syndrome scores between Mudan Granule group and epalrestat group(all P>0.05).Conclusion The combined application of Mudan Granules and epalestat in patients with DPN can effectively improve symptoms

关 键 词：糖尿病周围神经病变 木丹颗粒 依帕司他 震动感觉阈值 

分 类 号：R587.2[医药卫生—内分泌]