小剂量左旋甲状腺素治疗良性甲状腺结节的临床分组对照研究  

A Clinical Grouping Controlled Study of Low-dose Levothyroxine in the Treatment of Benign Thyroid Nodules

作　　者：王观成 WANG Guancheng(Endocrinology Department,Shen County People's Hospital,Liaocheng 252400,Shandong,China)

机构地区：[1]莘县人民医院内分泌科,山东聊城252400

出　　处：《系统医学》2024年第17期74-77,共4页Systems Medicine

摘　　要：目的探究小剂量左旋甲状腺素治疗良性甲状腺结节的临床效果。方法目的选取2021年2月—2022年10月莘县人民医院内分泌科收治的200例良性甲状腺结节患者。两组均应用左旋甲状腺素治疗,按照用药剂量分组,对照组(n=100)应用常规剂量,观察组(n=100)应用小剂量,比较两组患者的治疗指标以及不良反应率。结果观察组甲状腺结节大小(8.35±1.16)cm3优于对照组(10.65±1.52)cm3,差异有统计学意义(t=12.029,P<0.05),观察组内分泌代谢指标以及抗氧化应激指标优于对照组,差异有统计学意义(P均<0.05);观察组失眠以及呕吐患者各2例,对照组失眠和呕吐各4例,腹泻1例。结论使用小剂量左旋甲状腺素治疗良性甲状腺结节,效果以及安全性高。Objective To explore the clinical efficacy of low-dose levothyroxine in the treatment of benign thyroid nodules.Methods 200 patients with benign thyroid nodules admitted to the Endocrinology Department of Shen County People's Hospital from February 2021 to October 2022 were objectively selected.Both groups were treated with levo-thyroxine,they were grouped by medication dose,the control group(n=100)received conventional dose,while the ob-servation group(n=100)received low dose.The treatment indicators and adverse reaction rates of the two groups of pa-tients were compared.Results The size of thyroid nodules in the observation group was(8.35±1.16)cm3,better than the control group(10.65±1.52)cm3,the difference was statistically significant(t=12.029,P<0.05).The endocrine me-tabolism indicators and antioxidant stress indicators in the observation group were better than those in the control group,the differences were statistically significant(all P<0.05);There were 2 cases of insomnia and vomiting in the ob-servation group,4 cases of insomnia and vomiting in the control group,and 1 case of diarrhea.Conclusion The use of low-dose levothyroxine in the treatment of benign thyroid nodules has high efficacy and safety.

关 键 词：左旋甲状腺素 不同剂量 良性甲状腺结节 甲状腺结节 安全性 

分 类 号：R587.1[医药卫生—内分泌]