阿托伐他汀联合地塞米松对老年CSDH患者钻孔引流术后神经功能及血肿复发率的影响  

Effect of Atorvastatin Combined with Dexamethasone on Neurological Function and Haematoma Recurrence Rate after Drilling and Drainage in Elderly CSDH Patients

作　　者：吴春飞 宋张平 任洪清 WU Chunfei;SONG Zhangping;REN Hongqing(Neurosurgery Department,Tongzhou District People's Hospital,Nantong 226300,Jiangsu,China)

机构地区：[1]南通市通州区人民医院神经外科,江苏南通226300

出　　处：《系统医学》2024年第17期112-115,共4页Systems Medicine

摘　　要：目的分析慢性硬膜下血肿患者行钻孔引流术后给予阿托伐他汀联合地塞米松治疗的临床价值及其对患者神经功能以及血肿复发情况的影响。方法非随机选取2021年1月—2023年6月南通市通州区人民医院收治的50例慢性硬膜下血肿患者为研究对象,所有患者均通过钻孔引流术进行治疗。根据术后治疗方法不同分为两组,各25例。对照组行阿托伐他汀治疗,观察组增用地塞米松,比较两组血肿复发率、神经功能情况、术后残余血肿量与总有效率。结果观察组无血肿复发,对照组的复发率为24.00%(6/25),差异有统计学意义(χ^(2)=4.735,P<0.05)。治疗后,观察组格拉斯哥昏迷评分高于对照组,神经功能缺损相关评分低于对照组,差异有统计学意义(P均<0.05)。观察组术后2周及1个月的残余血肿量低于对照组,差异有统计学意义(P均<0.05)。观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。结论在钻孔引流术后,地塞米松与阿托伐他汀合用能够提升患者的治疗总有效率,改善术后神经功能恢复情况,减少残余血肿量,降低血肿的复发风险。Objective To analyse the clinical value of atorvastatin combined with dexamethasone treatment in patients with chronic subdural haematoma after drilling and drainage,and its effect on patients'neurological function and hae-matoma recurrence.Methods Fifty patients with chronic subdural hematoma admitted to Tongzhou District People's Hospital in Nantong City from January 2021 to June 2023 were non-randomly selected as the research objects.All pa-tients were treated with drilling and drainage surgery.According to different postoperative treatment methods,they were divided into two groups,with twenty-five cases in each group.The control group received atorvastatin treatment,while the observation group received dexamethasone.The neurological function,hematoma recurrence rate,total effec-tive rate,and postoperative residual hematoma volume were compared between the two groups.Results There was no recurrence of hematoma in the observation group,and the recurrence rate of hematoma in the control group was 24.00%(6/25),and the difference was statistically significant(χ^(2)=4.735,P<0.05).After treatment,the Glasgow Coma Scale in the observation group was higher than that in the control group,and the neurological deficit related scores were lower than those in the control group,and the differences were statistically significant(both P<0.05).The re-sidual hematoma volume in the observation group was lower than that in the control group at 2 weeks and 1 month af-ter surgery,and the differences were statistically significant(both P<0.05).The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).Conclusion After drilling drainage surgery,the combination of dexamethasone and atorvastatin can improve the overall treatment efficacy of patients,improve postoperative neurological function recovery,reduce residual hematoma volume,and lower the risk of hematoma recurrence.

关 键 词：慢性硬膜下血肿 钻孔引流术 地塞米松 阿托伐他汀 神经功能 血肿复发 

分 类 号：R651.1[医药卫生—外科学]