他汀类药物联合非洛地平缓释片治疗老年单纯性收缩期高血压的效果评价  

Evaluation of the Efficacy of Statins Combined with Sustained-Release Tablets of Felodipine in the Treatment of Elderly Patients with Isolated Systolic Hypertension

作　　者：刘妮娜 宗敏 李菊芳 LIU Nina;ZONG Min;LI Jufang(Pharmacy Department,Suzhou Ninth People's Hospital,Suzhou 215200,Jiangsu,China)

机构地区：[1]苏州第九人民医院药剂科,江苏苏州215200

出　　处：《系统医学》2024年第17期191-194,共4页Systems Medicine

摘　　要：目的分析他汀类药物联合非洛地平缓释片治疗老年单纯性收缩期高血压患者的效果。方法非随机选取2022年12月—2023年8月苏州第九人民医院收治的40例单纯性收缩期高血压老年患者为研究对象,按治疗方法分为两组,每组20例。对照组接受非洛地平缓释片常规治疗,观察组在其基础上联合使用阿托伐他汀钙片。比较两组血压水平、血脂指标水平、炎性因子指标、不良反应发生率。结果治疗后,观察组收缩压、血脂指标水平、血清炎性因子水平低于对照组,差异有统计学意义(P均<0.05)。观察组不良反应发生率为5.00%(1/20),低于对照组的35.00%(7/20),差异有统计学意义(χ^(2)=5.625,P<0.05)。结论采用他汀类药物结合非洛地平缓释片治疗老年单纯性收缩期高血压,可以提升疗效,改善血脂水平,降低血清炎症因子水平。Objective To analyze the effect of statins combined with felodipine extended-release tablets in the treat-ment of elderly patients with simple systolic hypertension.Methods Forty cases of elderly patients with simple sys-tolic hypertension admitted to the Ninth People's Hospital of Suzhou from December 2022 to August 2023 were non-randomly selected as the study subjects,and were divided into two groups of twenty cases each according to the treat-ment method.The control group received conventional treatment with felodipine extended-release tablets,and the ob-servation group used atorvastatin calcium tablets in combination on its basis.Compared the two groups'blood pressure level,blood lipid level,inflammatory factor indexes,and the incidence of adverse reactions.Results After treatment,the systolic blood pressure,blood lipid index levels,and serum inflammatory factor levels of the observation group were lower than those of the control group,and the differences were statistically significant(all P<0.05).The incidence rate of adverse reactions in the observation group was 5.00%(1/20),which was lower than 35.00%(7/20)in the con-trol group,and the difference was statistically significant(χ^(2)=5.625,P<0.05).Conclusion The use of statins combined with felodipine extended-release tablets for the treatment of simple systolic hypertension in the elderly enhances effi-cacy,improves lipid levels,and reduces serum inflammatory factor levels.

关 键 词：单纯性收缩期高血压 非洛地平 阿托伐他汀钙 血压 血脂 不良反应 

分 类 号：R4[医药卫生—临床医学]