熟地锁阳方治疗特发性肺纤维化的回顾性临床研究  

Retrospective clinical study of Shudi Suoyang decoction in the treatment of idiopathic pulmonary fibrosis

作　　者：张宁 郭亚丽[2] 刘建[2] 彭艳茹 崔嘉树 王玉光[2] ZHANG Ning;GUO Yali;LIU Jian;PENG Yanru;CUI Jiashu;WANG Yuguang(Shunyi Hospital of Beijing Hospital of Traditional Chinese Medicine,Beijing 100010,China;Beijing Hospital of Traditional Chinese Medicine,Capital Medical University,Beijing 100010,China;Beijing University of Chinese medicine,Beijing 100029,China)

机构地区：[1]北京中医医院顺义医院,北京100010 [2]首都医科大学附属北京中医医院,北京100010 [3]北京中医药大学,北京100029

出　　处：《现代中西医结合杂志》2024年第16期2217-2221,2232,共6页Modern Journal of Integrated Traditional Chinese and Western Medicine

基　　金：高层次公共卫生技术人才培养建设项目计划(学科带头人-01-16);首都卫生发展科研专项项目(首发2020-2-2233)。

摘　　要：目的评价熟地锁阳方治疗特发性肺纤维(IPF)的临床疗效,为该方的进一步开发和临床应用提供科学依据。方法收集2018年1月—2022年12月就诊于首都医科大学附属北京中医医院呼吸科门诊且诊断为IPF的患者资料。根据患者用药情况分为对照组26例和治疗组35例,对照组应用吡非尼酮口服治疗,治疗组应用熟地锁阳方加减治疗,2组疗程均为3个月。比较2组患者治疗前后的中医证候积分、莱斯特咳嗽生命质量问卷评分(LCQ)、肺功能、改良的医学研究委员会呼吸困难评分(mMRC)、咳嗽及呼吸困难的视觉模拟评分(VAS)、6 min步行距离(6MWD)、经皮血氧饱和度(SpO 2)。结果与治疗前比较,治疗后2组中医证候积分、mMRC评分、咳嗽及呼吸困难VAS评分均明显降低(P均<0.05),LCQ评分、用力肺活量占预计值百分比(FVC%)、一氧化碳弥散量占预计值百分比(DLco SB%)、肺活量占预计值百分比(VC MAX%)、6MWD及SpO 2均明显增加(P均<0.05)。与对照组比较,治疗后治疗组的中医证候积分、mMRC评分、咳嗽及呼吸困难VAS评分更低(P<0.05),LCQ评分更高(P<0.05),2组FVC%、DLco SB%、VC MAX%、6MWD、SpO 2比较差异均无统计学意义(P均>0.05)。治疗组临床总有效率为80.0%(28/35),对照组为76.9%(20/26),2组比较差异无统计学意义(P>0.05)。2组患者血常规、肝肾功能均未见明显异常;对照组中3例患者出现不良反应,治疗组未见明显不良反应。结论熟地锁阳方是治疗IPF患者有效复方,可减轻患者咳嗽、呼吸困难等临床症状,改善其肺功能,提高患者活动耐力及增加机体携氧量。Objective It is to evaluate the clinical curative effect of Shudi Suoyang decoction on Idiopathic pulmonary fibrosis(IPF),and to provide scientific evidences for the further development and clinical application of this decoction.Methods The data of patients diagnosed with IPF in the outpatient room of Respiratory Department of Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University from January 2018 to December 2022 were collected.The patients were divided into control group(n=26)and treatment group(n=35)according to their drug use.The control group was treated with pirfenidone,and the treatment group was treated with modified Shudi Suoyang decoction,both groups were treated for 3 months.The scores of traditional Chinese medical syndrome,scores of Lester Cough Quality of Life Questionnaire(LCQ),lung function,mMRC scores,scores of visual analog scale(VAS)for cough and dyspnea,6-minute walking test(6MWT),and percutaneous oxygen saturation SpO 2 of the patients in the two groups were compared before and after treatment.Results Compared with before treatment,traditional Chinese medical syndrome scores,mMRC scores,VAS scores of cough and dyspnea were significantly decreased after treatment(all P<0.05),wile the LCQ scores,FVC%,DLco SB%,VC MAX%,6MWD and SpO 2 were significantly increased(all P<0.05).Compared with the control group,the traditional Chinese medical syndrome scores,mMRC scores,VAS scores of cough and dyspnea in the treatment group were significantly lower while LCQ scores was significantly higher after treatment(all P<0.05),there were no significant differences in FVC%,DLco SB%,VC MAX%,6MWD,SpO 2%between the two groups after treatment(all P>0.05).The total effective rate was 80.00%(28/35)in the treatment group and 76.92%(20/26)in the control group,and there was no significant difference between the two groups(P>0.05).There were no obvious abnormalities in blood routine,liver and kidney function in the two groups.Adverse reactions occurred in 3 cases of patients in the contr

关 键 词：特发性肺纤维化 熟地锁阳方 肺功能 

分 类 号：R563.9[医药卫生—呼吸系统]