新生儿肺炎患儿血清IL-16、IL-10、PCT水平及诊断疾病严重程度价值  

Serum interleukin-16,interleukin-10 and procalcitonin of neonates with pneumonia and their diagnostic values for differential the disease severity of pneumonia

作　　者：刘雪 宋秀云 王占晖 王凌燕 LIU Xue;SONG Xiuyun;WANG Zhanhui;WANG Lingyan(JiaozhouCenterHospital,Qingdao,ShandongProvince,266300)

机构地区：[1]青岛市胶州中心医院,266300

出　　处：《中国计划生育学杂志》2024年第10期2363-2366,2371,共5页Chinese Journal of Family Planning

基　　金：青岛市医疗卫生重点学科建设项目。

摘　　要：目的:探究新生儿肺炎患儿血清白介素-16(IL-16)、(IL-10)、降钙素原(PCT)水平变化及用于诊断疾病严重程度价值。方法:回顾性收集2021年2月-2023年6月本院收治的新生儿肺炎患儿92例临床资料为观察组,同期出生的健康新生儿90例为对照组。比较两组血清IL-16、IL-10、PCT水平,使用受试者工作特征(ROC)曲线分析血清IL-16、IL-10、PCT诊断新生儿肺炎价值。根据观察组新生儿肺炎患儿严重程度分为非重症组(n=61)及重症组(n=31),比较不同严重程度患儿血清IL-16、IL-10、PCT水平,ROC曲线分析血清IL-16、IL-10、PCT对新生儿肺炎患儿严重程度的诊断价值。结果:观察组血清IL-16(336.82±100.51 ng/L)、IL-10(12.74±3.71 ng/L)、PCT(6.34±2.18μg/L)均高于对照组(123.65±29.74 ng/L、8.94±1.87 ng/L、3.51±1.33μg/L),ROC曲线分析显示,血清IL-16、IL-10、PCT诊断新生儿肺炎的曲线下面积(AUC)分别为0.984、0.815、0.873(均P<0.05);重症组血清IL-16、IL-10、PCT均高于非重症组,ROC曲线分析显示,血清IL-16、IL-10、PCT诊断新生儿肺炎患儿严重程度的AUC分别为0.964、0.757、0.866(均P<0.05)。结论:血清IL-16、IL-10、PCT水平能有效诊断新生儿肺炎,且对判断新生儿肺炎患儿严重程度有一定应用价值。Objective:To explore the changes of the serum interleukin-16(IL-16),interleukin-10(IL-10)and procalcitonin(PCT)of neonates with pneumonia,and to study the diagnostic values of the IL-16,IL-10 and PCT levels of the neonates for differential the disease severity of their pneumonia.Methods:The clinical data of 92 neonates with pneumonia admitted to hospital from February 2021 to June 2023 were collected retrospectively and these neonates were included in observation group.9o healthy neonates born during the same period were included in control group.The serum levels of IL-16,IL-10 and PCT of the neonates were compared between the two groups.Receiver operating characteristic(ROC)curve was used to analyze the values of serum IL-16,IL-10 and PCT levels of the neonates for diagnosing their pneumonia.According to the severity of the neonatal pneumonia in the observation group,the neonates were divided into group A(61 neonates without severe pneumonia)and group B(31 neonates with severe pneumonia).The serum levels of IL-16,IL-10 and PCT of the neonates were compared between group A and group B.ROC curve was used to analyze the values of serum IL-16,IL-10 and PCT levels of the neonates for diagnosing their severity of pneumonia.Results:The serum levels of IL-16(336.82±100.51 ng/L),IL-10(12.74±3.71 ng/L)and PCT(6.34±2.18μg/L)of the neonates in the observation group were significantly higher than those(123.65±29.74 ng/L,8.94±1.87 ng/L and 3.51±1.33μg/L)of the neonates in the control group.ROC curve analysis showed that the area under the curve (AUC) of the serum IL-16 level, the IL-10 level and the PCT level of the neonates for diagnosing their pneumonia were 0.984, 0.815 and 0.873, respectively (all P<0.05). The serum levels of IL-16, IL-10 and PCT of the neonates in group A were significantly higher than those of the neonates in group B. ROC curve analysis showed that theAUC of serum IL-16, IL-10 and PCT of the neonates for diagnosing their severity of pneumonia were 0.964, 0.757 and0.866, respectively (all P<0.05)

关 键 词：新生儿肺炎 血清学指标 白介素-16 白介素-10 降钙素原 严重程度 

分 类 号：R722.135[医药卫生—儿科]