备孕女性BMI对IVF/ICSI-ET妊娠结局的影响  

Efcts of the body mass index of women who prepared for pregnancy on their pregnancy outcomes after invitro fertiliza-tion/intracy toplasmic sperm injection and embryo transfer

作　　者：王斌[1] 薛婧 周文静 倪冬冬 王昭阳 刘乔 王爱红[1] WANG Bin;XUE Jing;ZHOU Wenjing;NI Dongdong;WANG Zhaoyang;LIU Qiao;WANG Aihong(Ninth Medical Center of Chinese PLA General Hospital(Strategic Support Force Medical Center),Beijing,100101)

机构地区：[1]解放军总医院第九医学中心(原战略支援部队特色医学中心),北京100101

出　　处：《中国计划生育学杂志》2024年第10期2377-2381,2385,共6页Chinese Journal of Family Planning

基　　金：军委后勤保障部卫生局计生项目(22JSZ07)。

摘　　要：目的:探讨体外受精/卵胞质内单精子注射-胚胎移植(IVF/ICSI-ET)对不同体质指数(BMI)女性患者临床结局的影响。方法:回顾性分析2020年1月-2023年3月本中心生殖中心接受IVF/ICSI-ET治疗的女性患者临床资料,根据女性BMI分为低体质量组(BMI<18.5kg/m^(2))、正常体质量组(18.5kg/m^(2)≤BMI<24.9kg/m^(2))、超重组(BMI≥24.9kg/m^(2)),比较3组行IVF/ICSI-ET助孕临床结局,logistic回归分析影响IVF/ICSI-ET临床妊娠率和活产率相关影响因素。结果:3组不孕年限、BMI、Gn用量、不孕原因存在差异(P<0.05)。低体质量组(36%,31/86)、正常体质量组(39.8%,276/693)、超重组(43.2%,108/250)临床妊娠率无差异,流产率(16.1%,5/31)、(10.1%,28/276)、(38.0%,41/108)有差异(P<0.05),活产率(30.2%,26/86)、(34.8%,241/693)、(26.4%,66/250)有差异(P<0.05)。logistic多因素回归分析显示,BMI超重和Gn用量多是影响辅助生殖后临床妊娠的因素,Gn用量多是影响辅助生殖后妊娠活产的因素(均P<0.05)。结论:备孕女性行IVF治疗前,使BMI达到或接近正常,以改善IVF/ICSI-ET助孕的妊娠结局。Objective:To investigate the effects of invitro fertilization/intracytoplasmic sperm injection and embryo transfer(IVF/ICSI ET)of women with different body mass index(BMI)value who prepared for pregnancy on their pregnancy outcomes.Methods:A retrospective analysis was conducted on the data of the women who received IVF/IC-SI-ET treatment from January 2020 to March 2023.These women were divided into three groups according to their BMI values,including group A(women with BMI<18.5kg/m2),group B(women with 18.5kg/m°≤BMI<24.9kg/m2)and group C(women with BMI≥24.9kg/m2).The clinical outcomes of the women after IVF/ICSIET were com-pared among the three groups.Logistic regression analysis was used to analyze the related factors affecting the clinical pregnancy rate and the live birth rate of the women in the three groups after IVF/ICSI-ET.Results:There were signif-icant differences in the duration of infertility,the BMI value,the dosage of Gn used and the causes of infertility of the women among the three groups(P<0.05).There was no significant difference in the clinical pregnancy rates of the women among group A(36%,31/86),group B(39.8%,276/693)and group C(43.2%,108/250).The abortion rate of the women in group A(16.1%,5/31),in group B(10.1%,28/276)and in group C(38.0%,108/250)had no.significantly different.The live birth rate of the women in group A(30.2%,26/86),in group B(34.8%,241/693)and in group C(26.4%,66/250)had significantly different(P<0.05).Logistic multivariate regression analysis showed that the overweight and the high dosage of Gn used of the women with IVF/ICSI-ET were the factors affecting their clinical pregnancy,and the high dosage of Gn used of the women with IVF/ICSIET was the factors af-fecting their live birth(all P<0.05).Conclusion:Before undergoing IVF treatment,the achieving or approaching nor-mal BMI of the women who prepared for pregnancy can improve their clinical outcomes after IVF/ICSI-ET.

关 键 词：备孕女性 体质指数 辅助生殖 妊娠结局 影响因素 

分 类 号：R714.8[医药卫生—妇产科学]