超声监测结合BUN、UA水平预测PE并发FGR孕产妇不良结局价值  

Value of the ultrasound monitoring combined with the levels of blood urea nitrogen and uric acid of pregnant women with preeclampsia complicated with fetal growth restriction for predicting their adverse pregnaney outcomes

作　　者：高海侠[1] 张晓月 高京京 刘晓铮 刘双双 刘晓华[1] GAO Haixia;ZHANG Xiaoyue;GAO Jingjing;LIU Xiaozheng;LIU Shuangshuang;LIU Xiaohua(Chengde Central Hospital,Chengde,Hebei Province,067000)

机构地区：[1]河北省承德市中心医院,067000

出　　处：《中国计划生育学杂志》2024年第10期2391-2395,共5页Chinese Journal of Family Planning

基　　金：承德市科技计划项目(202301A018)。

摘　　要：目的:探讨超声胎儿监测结合血尿素氮(BUN)和尿酸(UA)水平预测子痫前期(PE)并发胎儿生长受限(FGR)患者不良结局价值。方法:回顾性收集2020年1月-2023年5月本院就诊的PE患者,其中并发FGR 106例为观察组,未并发FGR患者106例为对照组,比较两组血BUN、UA水平,超声胎儿静脉导管收缩期峰值速度(PSV)、舒张期峰值速度(EDV)、平均时间最大血流速度(Vmax),统计新生儿及孕妇不良结局。结果:观察组血BUN(5.03±1.22mmol/L)、UA(435.54±52.13mmol/L)高于对照组(4.01±1.30 mmol/L、391.60±60.88 mmol/L),PSV(0.85±0.12cm/s)、EDV(0.78±0.11cm/s)、Vmax(0.81±0.13cm/s)低于对照组(0.89±0.11 cm/s、0.96±0.14 cm/s、0.98±0.12 cm/s),新生儿不良结局总发生率(67.9%)高于对照组(15.1%),孕妇不良妊娠结局总发生率(38.7%)高于对照组(20.8%);观察组发生新生儿不良结局患者血BUN、UA高于未发生新生儿不良结局患者,而超声胎儿静脉血流参数均低于未发生新生儿不良结局患者(均P<0.05)。血BUN、UA、PSV、EDV、Vmax及联合预测新生儿不良结局的曲线下面积分别为0.735、0.760、0.643、0.809、0.670和0.706,联合预测的灵敏性达到100.0%。结论:PE并发FGR患者BUN、UA水平异常升高,超声胎儿静脉血流参数异常降低,上述超声及血指标预测新生儿不良结局有一定临床指导价值。Objective:To explore the value of the ultrasound monitoring combined with the levels of blood urea nitrogen(BUN)and uric acid(UA)of pregnant women with preeclampsia(PE)complicated with fetal growth restriction(FGR)for predicting their adverse pregnancy outcomes.Methods:106 pregnant women with PE from January 2020 to May 2023 were collected retrospectively,including 106 women complicated with FGR in observation group and 106 women without FGR in control group.The levels of BUN and UA,the values of peak systole velocity(PSV),peak diastolic velocity(EDV)and average maximum blood flow velocity(Vmax)of the venous catheter of the women were compared between the two groups.The adverse outcomes of the newborns and the pregnant women in the two groups were counted.Results:The levels of BUN(5.03±1.22mmol/L)and UA(435.54±52.13mmol/L)of the women in the observation group were significantly higher than those(4.01±1.30 mmol/L and 391.60±60.88 mmol/L)of the women in the control group.The values of PSV(0.85±0.12cm/s),EDV(0.78±0.11cm/s)and Vmax(0.81±0.13cm/s)of the women in the observation group were significantly lower than those(0.89±0.11 cm/s,0.96±0.14 cm/s and 0.98±0.12 cm/s)of the women in the control group.The total incidence of the neonatal adverse outcomes(67.9%)in the observation group was significantly higher than that(15.1%)of the control group,and the total incidence of the maternal adverse pregnancy outcomes(38.7%)in the observation group was significantly higher than that(20.8%)in the control group.In the observation group,the levels of BUN and UA of the women with the adverse neonatal outcomes were significantly higher than those of the women without the adverse neonatal outcomes,while the ultrasonic fetal venous blood flow parameters of the women with the adverse neonatal outcomes were significantly lower than those of the women without the adverse neonatal outcomes(all P<0.05).The areas under the curve of the BUN level,the UA level,the PSV value,the EDV value,the Vmax value,and the levels of BUN and UA

关 键 词：子痫前期 胎儿生长受限 超声监测 血尿素氮 尿酸 不良妊娠结局 预测价值 

分 类 号：R445.1[医药卫生—影像医学与核医学] R714.5[医药卫生—诊断学]