血清25-(OH)D联合Hcy预测继发性不孕症患者治疗后妊娠的价值  

Predictive value of the serum 25-hydroxyvitamin D level combined with the homocysteine level of women with secondary in-fertility for their pregnancy situation after treatment

作　　者：赵峰 周望展 林雯雯 ZHAO Feng;ZHOU Wangzhan;LIN Wenwen(Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine,Wenzhou,Zhejiang Province,325000)

机构地区：[1]浙江省温州市中西医结合医院,325000

出　　处：《中国计划生育学杂志》2024年第10期2396-2399,2405,共5页Chinese Journal of Family Planning

摘　　要：目的:探讨继发性不孕症患者血清25-羟基维生素D[25-(OH)D]、同型半胱氨酸(Hcy)水平及对治疗后妊娠的预测价值。方法:收集2022年1月-2023年8月本院就诊治疗的继发性不孕症患者161例为不孕组,正常备孕女性161例作为健康组,比较两组一般资料及血清25-(OH)D、Hcy水平;不孕组治疗并随访6个月,根据治疗后妊娠情况分为临床妊娠组和未妊娠组,采用受试者工作特征(ROC)曲线分析血清25-(OH)D、Hcy水平对继发性不孕症患者治疗后妊娠的预测价值。结果:不孕组血清Hcy水平(10.50±5.57μmol/L)高于健康组(21.02±5.62μmol/L),25-(OH)D水平(18.31±6.34 ng/ml)低于健康组(21.02±5.62 ng/ml);不孕组中临床妊娠组血清25-(OH)D水平(19.84±6.20 ng/ml)高于未妊娠组(15.52±6.60 ng/ml),Hcy水平(8.72±5.29μmol/L)低于未妊娠组(13.75±6.08μmol/L)(均P<0.05)。25-(OH)D联合Hcy预测继发不孕患者治疗后妊娠的曲线下面积为0.884,高于25-(OH)D(0.767)、Hcy(0.842)单独预测,联合预测的敏感度82.5%、特异度80.8%。结论:继发性不孕症患者血清25-(OH)D呈低表达、Hcy呈高表达,二者联合检测对患者治疗后妊娠有一定预测价值。Objective:To investigate the predictive value of the serum 25-hydroxyvitamin D(25-(OH)D)level combined with the homocysteine(Hcy)level of women with secondary infertility for their pregnancy situation after treatment.Methods:161 women with secondary infertility from January 2022-August 2023 were selected in study group,and 161 normal pregnant women were selected in control group.The general data and the serum 25-(OH)D and Hcy levels of the women were compared between the two groups.The women in the study group were followed up for 6 months.According to the pregnancy situation after treatment,the women in the study group were divided into group A(women with clinical pregnancy)and group B(women without clinical pregnancy).Receiver operating characteristic(ROC)curve was used to analyze the predictive value of the serum 25-(OH)D and Hcy levels of the women in the study group for their pregnancy after treatment.Results:The serum Hcy level(10.50±5.57μmol/L)of the women in the study group was significantly higher than that(21.02±5.62μmol/L)of the women in the control group.The level of 25-(OH)D(18.31±6.34 ng/ml)of the women in the study group was significantly lower than that(21.02±5.62 ng/ml)of the women in the control group.The serum 25-(OH)D(19.84±6.20 ng/ml)level of the women in group A was significantly higher than that(15.52±6.60 ng/ml)of the women in group B,and the Hcy level(8.72±5.29μmol/L)of the women in group A was significantly lower than that(13.75±6.08μmol/L)of the women in group B(all P<0.05).The area under the curve of the 25-(OH)D level combined with the Hcy level of the women in the study group for predicting their pregnancy after treatment was 0.884,which was significantly higher than that(0.767)of the 25-(OH)D level or that(0.842)of the Hcy level alone.The sensitivity and the specificity of the 25-(OH)D level combined with the Hcy level of the women in the study group for predicting their pregnancy after treatment were 82.5%and 80.8%.Conclusion:The serum 25-(OH)D3 level of the women with

关 键 词：继发性不孕症 25-羟基维生素D 同型半胱氨酸 治疗后妊娠 预测效能 

分 类 号：R711.6[医药卫生—妇产科学]