miR-29b、ESM1联合血栓弹力图检测诊断早发型PE价值  

Diagnostic value of the levels of miR 29b and ndothelial cell speciftic molecule-1 combined with thromboelastography results of pregnant women for their early onset preeclampsia

作　　者：范徐妃 羊亚莉 聂桂兰 楼建义 FAN Xufei;YANG Yali;NIE Guilan;LOU Jianyi(J inhua Hospital Affiliated to Zhejiang University,Zhejiang Province,321000;J inhua Maternal and Child Health Care Hos pital of Zhejiang Province)

机构地区：[1]浙江大学附属金华医院,321000 [2]浙江省金华市妇幼保健院

出　　处：《中国计划生育学杂志》2024年第10期2400-2405,共6页Chinese Journal of Family Planning

基　　金：2019年度浙江省自然科学基金项目(LQ19H040002);2023年度金华市重大(重点)科技计划项目(2023-3-147)。

摘　　要：目的:探究miR-29b、内皮细胞特异性分子-1(ESM1)及血栓弹力图联合检测对早发型子痫前期(PE)的诊断价值。方法:回顾性收集2022年1月-2023年12月在本院接受治疗的93例早发型PE患者为病例组,产前检查正常妊娠且分娩的孕妇93例为对照组。分析两组血清miR-29b、ESM1水平,检测血栓弹力图情况,探究各指标对患者早发型PE及其病情严重程度的诊断效能。结果:病例组血清miR-29b(1.45±0.54)、ESM1(326.15±41.12 mmol/L)水平均高于对照组(1.23±0.45、196.23±32.15 mmol/L),反应时间、凝血时间、综合凝血指数均低于对照组,最大振幅高于对照组(均P<0.05),两组水平夹角比较无差异(P>0.05);miR-29b、ESM1、反应时间、凝血时间、最大振幅、综合凝血指数诊断早发型PE的曲线下面积(AUC)分别为0.900、0.921、0.888、0.821、0.788、0.899,而各指标联合诊断的AUC值为0.977。病例组中,PE轻度组和重度组水平夹角无差异(P>0.05),重度组血清miR-29b、ESM1、最大振幅高于轻度组,反应时间、凝血时间、综合凝血指数均低于轻度组(均P<0.05),miR-29b、ESM1、反应时间、凝血时间、最大振幅、综合凝血指数诊断重度早发型子痫前期的AUC值分别为0.856、0.884、0.940、0.667、0.754、0.831,上述指标联合诊断的AUC值为0.892。结论:血清miR-29b、ESM1联合血栓弹力图联合检测诊断早发型PE价值较高,且对早发型PE病情严重程度也有较高的诊断效能。Objective:To explore the diagnostic value of the levels of miR-29b and ndothelial cell specific molecule-1(ESM1)combined with thromboelastography results of pregnant women for their early-onset preeclampsia(PE).Methods:93 pregnant women with early-onset PE treated in hospital from January 2022 to December 2023 were selected in study group retrospectively,and another 93 pregnant women with normal prenatal examinations were selected in control group.The levels of the serum miR-29b and ESM1 of the women in the two groups were analyzed,and the thromboelastography results of the women in the two groups were examined.The diagnostic efficacies of the levels of the serum miR-29b and ESM1 and the thromboelastography results of the women in the study group for their early-onset PE and the severity of their PE were explored.Results:The levels of serum miR-29b(1.45±0.54)and ESM1(326.15±41.12 mmol/L)of the women in the study group were significantly higher than those(1.23±0.45 and 196.23±32.15 mmol/L)of the women in the control group,and the values of the reaction time,the coagulation time and the comprehensive coagulation index of the women in the study group were significantly lower than those of the women in the control group.The maximum amplitude of the women in the study group was significantly higher than that of the women in the control group(all P<0.05),and there was no significant difference in the horizontal angle of the women between the two groups(P>0.05).The area under the curve(AUC)of the miR-29blevel,the ESM1level,the reaction time value,the clotting time value,the maximum amplitude value and the comprehensive coagulation index value of the women for diagnosing their early-onset PE were 0.900,0.921,0.888,0.821,0.788,and 0.899,respectively,while the AUC value of the combined the miR-29band ESM1levels,and the values of reaction time,clotting time,maximum amplitude and comprehensive coagulation index each index of the women for diagnosing their early-onset PE was 0.977.In the study group,there was no significa

关 键 词：早发型子痫前期 病情程度 miR-29b 内皮细胞特异性分子-1 血栓弹力图 诊断价值 

分 类 号：R714.244[医药卫生—妇产科学]