GDM患者血清CCL11、IL-13水平预测PE发生风险价值  

Predictive values of the levels of serum chemokine ligand 11 and interleukin-13 of pregnant women with gestational diabetes mellitus for their risk of preeclampsia

作　　者：郑皓文 戚挺 周甜甜[1] 马善朵 王维俊[1] ZHENG Haowen;QI Ting;ZHOU Tiantian;MA Shanduo;WANG Weijun(Lianyungang First People's Hospital,Lianyungang,Jiangsu Province,222000)

机构地区：[1]江苏省连云港市第一人民医院,222000

出　　处：《中国计划生育学杂志》2024年第10期2429-2433,共5页Chinese Journal of Family Planning

摘　　要：目的:探讨血清趋化因子配体11(CCL11)、白介素-13(IL-13)水平对妊娠期糖尿病(GDM)患者发生子痫前期(PE)风险的预测价值。方法:回顾性收集2021年9月-2023年8月本院收治的GDM患者144例临床资料,根据是否发生PE分为GDM合并PE组(n=52)和单纯GDM组(n=92),同期产前检查正常孕妇120例作为对照组。比较3组血清CCL11、IL-13水平;采用受试者工作特性(ROC)曲线评估血清CCL11、IL-13对GDM患者发生PE的预测价值;采用二分类logistic逐步回归分析探讨GDM患者发生PE影响因素。结果:血清CCL11水平GDM合并PE组(77.98±8.35 pg/ml)、单纯GDM组(44.69±5.13 pg/ml)、对照组(25.73±4.05 pg/ml)依次降低,血清IL-13水平GDM合并PE组(12.43±2.84 pg/ml)、单纯GDM组(18.23±3.37 pg/ml)、对照组(27.42±4.14 pg/ml)依次升高(均P<0.05)。血清CCL11、IL-13及两项指标联合预测GDM患者发生PE的曲线下面积(AUC)分别为0.768、0.853、0.911,特异度分别为56.1%、65.6%、86.4%,灵敏度分别为90.7%、90.7%、84.5%。回归分析显示,孕前BMI高(OR=2.073)、HOMA-IR高(OR=2.333)、CCL11≥61.10pg/ml(OR=2.697)、IL-13≤15.31pg/ml(OR=0.299)是GDM患者发生PE的独立危险因素(均P<0.05)。结论:GDM患者血清CCL11高表达、IL-13低表达与发生PE有关,且这两项指标可作为预测GDM患者发生PE风险的生物标记物。Objective:To investigate the predictive values of the serum chemokine ligand 11(CCL11)and interleukin-13(IL-13)levels of pregnant women with gestational diabetes mellitus(GDM)for their risk of preeclampsia(PE).Methods:The clinical data of 144 pregnant women with GDM admitted to the hospital from September 2021 to August 2023 were selected as the subjects of this study.According to the occurrence of preeclampsia or not,these women were divided into group A(52 women with GDM complicated with PE)and group B(92 women with GDM only).In addition,120 normal pregnant women were selected in group C during the same period.The levels of serum CCL11 and IL-13 of the women were compared among the three groups.The predictive value of the serum CCL1l and IL-13 levels of the women with GDM for their PE was evaluated by receiver operator characteristic(ROC)curve.The factors influencing the occurrence of PE of the women with GDM were investigated by binary logistic step by step regression analysis.Results:The serum CCL11 level of the women in group A(77.98±8.35 pg/ml),in group B(44.69±5.13 pg/ml)and in group C(25.73±4.05 pg/ml)had decreased gradually.The serum level of IL-13 of the women in group A(12.43±2.84 pg/ml),in group B(18.23±3.37 pg/ml)and in group C(27.42±4.14 pg/ml)had increased gradually(all P<0.05).The area under the curve(AUC)of the serum CCL11 level,the IL-13 level and the combination of the serum CCL11 and IL-13 levels of the women with GDM for predicting their PE were 0.768,0.853 and 0.91l,respectively,the specificity of which were 56.1%,65.6%and 86.4%,respectively,and the sensitivity of which were 90.7%,90.7%and 84.5%,respectively.Regression analysis showed that the high pre-pregnancy BMI(OR=2.073),the high HOMA-IR values(OR=2.333),the CCL11 level≥61.10pg/ml(OR=2.697),and the IL-13 level≤15.31pg/ml(OR=0.299)of the women with GDM were the independent risk factors of their PE occurrence(all P<0.05).Conclusion:The high expression of the CCL11 and the low expression of IL-13 of the women with GDM are associa

关 键 词：妊娠期糖尿病 子痫前期 趋化因子配体11 白介素-13 预测价值 危险因素 

分 类 号：R714.256[医药卫生—妇产科学]