胺碘酮联合美托洛尔在冠心病合并心律失常患者中的应用  

Application of Amiodarone Combined with Metoprolol in Patients with Coronary Heart Disease Complicated with Arrhythmia

作　　者：伍立涛 尹恒冲 范存洁 WU Litao;YIN Hengchong;FAN Cunjie(Department of Cardiology,Ruyang County People's Hospital,Luoyang 471200,China)

机构地区：[1]汝阳县人民医院心内科,河南洛阳471200

出　　处：《临床医学工程》2024年第10期1219-1220,共2页Clinical Medicine & Engineering

摘　　要：目的分析胺碘酮联合美托洛尔治疗冠心病(CHD)合并心律失常患者的效果。方法80例CHD合并心律失常患者随机分为两组,对照组给予盐酸胺碘酮胶囊治疗,研究组在对照组基础上给予酒石酸美托洛尔缓释片治疗,比较两组的QTc间期、QT离散度(QTD)、血流动力学、临床疗效。结果治疗后,研究组的QTc间期长于对照组,QTD短于对照组,ESR、Fb均低于对照组,总有效率高于对照组(P<0.05)。两组的不良反应发生率比较,差异无统计学意义(P>0.05)。结论胺碘酮联合美托洛尔治疗CHD合并心律失常患者的效果显著,可延长QTc间期,缩短QTD,改善血流动力学,安全性高。Objective To analyze the effect of amiodarone combined with metoprolol in the treatment of patients with coronary heart disease(CHD)complicated with arrhythmia.Methods 80 patients with CHD complicated with arrhythmia were randomly divided into two groups.The control group was treated with amiodarone hydrochloride capsules,and the study group was treated with metoprolol tartrate sustained-release tablets on the basis of the control group.The QTc interval,QT dispersion(QTD),hemodynamics and clinical efficacy were compared between the two groups.Results After treatment,the QTc interval of the study group was longer than that of the control group,QTD was shorter than that of the control group,ESR and Fb were lower than those of the control group,and the total effective rate was higher than that of the control group(P<0.05).No significant difference was found in the incidence of adverse reactions between the two groups(P>0.05).Conclusions Amiodarone combined with metoprolol has significant effect and high safety in the treatment of patients with CHD complicated with arrhythmia,which can prolong QTc interval,shorten QTD,and improve hemodynamics.

关 键 词：冠心病 心律失常 胺碘酮 美托洛尔 血流动力学 

分 类 号：R541[医药卫生—心血管疾病]