胸腺法新辅助抗结核药物治疗对复治菌阳肺结核患者的影响  

Impact of Therapy of Thymalfasin Assisted with Anti-Tuberculosis Drugs on Patients with Smear-Positive Retreatment Pulmonary Tuberculosis

作　　者：马燕芳 赖金梅[1] 廖观连 MA Yanfang;LAI Jinmei;LIAO Guanlian(Department of Tuberculosis,Longyan Second Hospital,Longyan 364000,China)

机构地区：[1]龙岩市第二医院结核科,福建龙岩364000

出　　处：《临床医学工程》2024年第10期1221-1222,共2页Clinical Medicine & Engineering

摘　　要：目的分析胸腺法新辅助抗结核药物治疗肺结核(TB)的效果。方法116例复治菌阳TB患者随机分为两组,对照组予以抗结核药物治疗,观察组予以抗结核药物+胸腺法新治疗,比较两组的痰菌转阴率、肺功能、免疫功能。结果观察组治疗2个月、3个月的痰菌转阴率均高于对照组(P<0.05)。治疗后,观察组的FEV_(1)、FEV_(1)/FVC、FVC、CD4^(+)、CD3^(+)、CD4^(+)/CD8^(+)均高于对照组(P<0.05)。结论胸腺法新辅助抗结核药物治疗复治菌阳TB可提高痰菌转阴率,改善患者的肺功能与免疫功能。Objective To analyze the effect of thymalfasin assisted with anti-tuberculosis drugs in the treatment of patients with smear-positive retreatment pulmonary tuberculosis(TB).Methods 116 patients with smear-positive retreatment TB were randomly divided into two groups.The control group was treated with anti-tuberculosis drugs,and the observation group was treated with anti-tuberculosis drugs+thymalfasin.The sputum negative conversion rate,lung function and immune function were compared between the two groups.Results After 2 months and 3 months of treatment,the sputum negative conversion rates of the observation group were higher than those of the control group(P<0.05).After treatment,FEV_(1),FEV_(1)/FVC,FVC,CD4^(+),CD3^(+)and CD4^(+)/CD8^(+)of the observation group were higher than those of the control group(P<0.05).Conclusions Thymalfasin assisted with anti-tuberculosis drugs in the treatment of smear-positive retreatment TB can increase the sputum negative conversion rate and improve the lung function and immune function of patients.

关 键 词：胸腺法新 复治菌阳肺结核 肺功能 免疫功能 

分 类 号：R521[医药卫生—内科学]