新型抗菌药物依拉环素的研究进展  

Research progress of a new antibacterial drug eravacycline

作　　者：冯洁 谢俊艳 时友忠 安洪亮 FENG Jie;XIE Jun-yan;SHI You-zhong;AN Hong-liang(Department of Pharmacy,Nanjing Meishan Hospital,Nanjing JIANGSU 210039,China)

机构地区：[1]南京梅山医院药剂科,江苏南京210039

出　　处：《中国新药与临床杂志》2024年第9期641-646,共6页Chinese Journal of New Drugs and Clinical Remedies

摘　　要：依拉环素是一种新型全合成的含氟四环素类抗生素,具有广谱的抗菌活性。现有的临床试验表明,依拉环素在治疗各类复杂性感染中具有很好的有效性和安全性,尤其在针对多药耐药菌方面应用前景良好。本文从该药的化学结构、作用机制、抗菌谱、药动学/药效学、临床应用、耐药性等方面进行综述,为临床用药提供依据和参考。Eravacycline is a new class of fully synthetic fluortetracycline antibiotics with broad-spectrum antibacterial activity.The existing clinical trials have shown that eravacycline has good efficacy and safety in the treatment of various complex infections,especially in the application of multi-drug resistant bacteria.In this paper,the chemical structure,mechanism of action,antibacterial spectrum,pharmacokinetics/pharmacodynamics,clinical application,and drug resistance of eravacycline were reviewed in order to provide basis and reference for clinical drug use.

关 键 词：依拉环素 药理作用机制 临床研究 抗药性 细菌 

分 类 号：R978.1[医药卫生—药品]