基于“冲为血海”的分期针灸对肾虚痰湿型多囊卵巢综合征患者IVF-ET助孕结局及性激素、子宫内膜血流参数的影响  

Effects of Staging Acupuncture Based on“Flushing for a Sea of Blood”on IVF-ET Assisted Pregnancy Outcome,Sex Hormones and Endometrial Blood Flow Parameters in Patients with Kidney Deficiency Phlegm-Dampness Type Polycystic Ovary Syndrome

作　　者：任杏杏[1] 卫爱武[1] 宋红艳[1] 石少琦 崔天薇 何东杰[1] REN Xingxing;WEI Aiwu;SONG Hongyan;SHI Shaoqi;CUI Tianwei;HE Dongjie(Department of Reproductive Medicine,the First Affiliated Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou 450000,China)

机构地区：[1]河南中医药大学第一附属医院生殖医学科,河南郑州450000

出　　处：《河南医学研究》2024年第19期3589-3593,共5页Henan Medical Research

基　　金：河南省中医药科学研究专项课题(2019JDZX2019);河南省中医药科学研究专项课题(2019ZY2114)。

摘　　要：目的评价基于“冲为血海”的分期针灸对肾虚痰湿型多囊卵巢综合征患者体外受精-胚胎移植(IVF-ET)助孕结局及性激素、子宫内膜血流参数的影响。方法选取2020年1月至2022年1月于河南中医药大学第一附属医院生殖医学科接受治疗的60例肾虚痰湿型多囊卵巢综合征,分为对照组(30例)与联合组(30例)。对照组接受单纯卵泡期长方案促排卵,在阴道B超引导下经阴道穿刺取卵,取卵后72 h移植优质胚胎;联合组在对照组基础上接受基于“冲为血海”的分期针灸,直至取卵,IVF-ET后随访10个月观察妊娠结局。比较两组胚胎获得及种植情况、IVF-ET助孕结局,治疗前和治疗后子宫内膜血流参数、厚度、类型,性激素、中医证候积分,治疗期间不良反应。结果联合组获卵数、优质胚胎率、胚胎种植率、临床妊娠率、生化妊娠率、活产率更高(P<0.05)。与治疗前比较,治疗后两组血流搏动指数(PI)、血流阻力指数(RI),血清睾酮(T)水平降低,且联合组更低(P<0.05)。与治疗前比较,治疗后两组子宫内膜厚度、子宫内膜分型A型比例,血清孕酮(P)、雌二醇(E_(2))水平升高,且联合组更高(P<0.05)。两组不良反应发生率差异无统计学意义(P>0.05)。结论基于“冲为血海”的分期针灸治疗肾虚痰湿型多囊卵巢综合征可缓解中医症候,调节性激素、子宫内膜血流参数,改善子宫内膜形态,促进IVF-ET中胚胎的获得及种植,最终优化IVF-ET助孕结局。Objective To evaluate the effects of staging acupuncture based on“flushing for a sea of blood”on in vitro fertilization-embryo transfer(IVF-ET)assisted pregnancy outcome,sex hormones and endometrial blood flow parameters in patients with kidney deficiency phlegm-dampness type polycystic ovary syndrome.Methods From January 2020 to January 2022,60 patients with kidney deficiency phlegm-dampness-type polycystic ovary syndrome were admitted to the Department of Reproductive Medicine of the First Affiliated Hospital of Henan University of Traditional Chinese Medicine.They were divided into the control group(30 cases)and the combined group(30 cases),using random number table method.The control group received simple follicular phase long protocol ovulation induction,followed by transvaginal oocyte retrieval under the guidance of vaginal B ultrasound,and high-quality embryos were transplanted 72 h after ovulation.On the basis of the control group,the combined group was given staging acupuncture based on“flushing for a sea of blood”until eggs were taken,and the pregnancy outcome was observed at 10 month after IVF-ET follow-up.The two groups of conditions of embryo acquisition and implantation,IVF-ET assisted pregnancy outcome,endometrial blood flow parameters,thickness,type,sex hormones,scores of traditional Chinese medicine syndrome before and after treatment,and adverse reactions during treatment were compared.Results The number of eggs,high quality embryo rate,embryo implantation rate,clinical pregnancy rate,biochemical pregnancy rate and live birth rate in the combination group were higher(P<0.05).Compared with before treatment,blood flow pulsation index(PI),blood flow resistance index(RI),serum level of testosterone(T)of the two groups decreased after treatment,and the combined group was lower(P<0.05).Compared with before treatment,after treatment,endometrial thickness,endometrial type A ratio,serum levels of progesterone(P)and estradiol(E_(2))increased in the two groups,and higher in the combination group(P<

关 键 词：多囊卵巢综合征 肾虚痰湿型 分期针灸 体外受精-胚胎移植 

分 类 号：R246.3[医药卫生—针灸推拿学]