基于脑肠轴探讨肠道菌群调控腹泻型肠易激综合征的研究进展  

Research Progress on the Regulation of Gut Microflora in Diarrheal Irritable Bowel Syndrome Based on Brain-Gut Axis

作　　者：王宏吉 曹波 WANG Hongji;CAO Bo(Guizhou University of Traditional Chinese Medicine,Guiyang 550002,China;The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine,Guiyang 550000,China)

机构地区：[1]贵州中医药大学,贵州贵阳550002 [2]贵州中医药大学第一附属医院,贵州贵阳550000

出　　处：《中国民族民间医药》2024年第19期59-65,共7页Chinese Journal of Ethnomedicine and Ethnopharmacy

摘　　要：腹泻型肠易激综合征是以内脏高敏感性为主要发病机制的一种肠道功能紊乱性疾病,主要临床表现为精神刺激引发的腹痛腹泻,与中医学中肝郁脾虚型泄泻症状高度相似。近期有研究指出,在腹泻型肠易激综合征发病机制中,脑肠轴紊乱导致的内脏高敏感性是关键,肠道菌群失调亦会引起和加剧内脏高敏感性。文章就中枢和外周调控内脏高敏性的角度分析了肠道菌群对脑肠轴5-HT的调控作用,进一步丰富腹泻型肠易激综合征的中医药治疗理论,为临床诊疗提供新思路。The diarrheal irritable bowel syndrome is an intestinal dysfunction disease with visceral hypersensitivity as the main pathogenesis.The main clinical manifestation is abdominal pain diarrhea caused by mental stimulation,which is highly similar to the symptoms of liver stagnation and spleen deficiency in traditional Chinese medicine.Recent studies have pointed out that in the pathogenesis of diarrheal irritable bowel syndrome,visceral hypersensitivity caused by brain-gut axis disorder is the key,and gut microflora imbalance can also cause and exacerbate visceral hypersensitivity.This article analyzes the regulation effect of gut microflora on 5-HT of brain-gut axis from the perspective of central and peripheral regulation of visceral high sensitivity,further enriches the theory of traditional Chinese medicine treatment of diarrheal irritable bowel syndrome,and provides new ideas for clinical diagnosis and treatment.

关 键 词：腹泻型肠易激综合征 脑肠轴 内脏高敏感性 肠道菌群 5-羟色胺 

分 类 号：R259[医药卫生—中西医结合]