Study on HPLC-DAD Fingerprint of Xueshuan Xinmaining Capsules  

作　　者：Chuang ZHAO Yuling LIU Longfei LIN Chunmin WANG Hui LI Yujie YANG 

机构地区：[1]Chengde Medical College,Chengde 067000,China [2]Institute of Chinese Medicine,China Academy of Chinese Sciences,Beijing 100700,China [3]Chengde Neck Fukang Pharmaceutical Group Co.,Ltd.,Chengde 067000,China

出　　处：《Medicinal Plant》2024年第5期31-34,49,共5页药用植物（英文）

摘　　要：[Objectives]To establish the HPLC-DAD fingerprint of Xueshuan Xinmaining Capsule(XXC).[Methods]The chromatographic conditions for the analysis of XXC solution were as follows:XSelect HSS T3 column;acetonitrile-0.1%phosphoric acid water was used as mo-bile phase,gradient elution;flow rate:1.0 mL/min;column temperature 30℃;The injection volume is 10μL.The quality of XXC samples produced by different manufacturers was evaluated by similarity evaluation and cluster analysis.[Results]In theHPLC-dad fingerprints of 15 batches of XXC,23 common peaks were identified and 9 peaks were identified,and the similarity was greater than 0.95.According to the re-sults of cluster analysis,15 batches of XXC samples could be divided into two categories,S2,S5,S6,S7 and S8 batches belonged to category Ⅰ,and the rest batches belonged to category Ⅱ.[Conclusions]In this study,a representative and universal identification method of Xxc HPLC-DAD fingerprint was established.The method has high precision,stability and repeatability,is simple and reliable,and provides a pow-erful reference for further improving the quality evaluation system of XXC.

关 键 词：Xueshuan Xinmaining Capsule(XXC) HPLC-DAD FINGERPRINT Identification of chemical component Quality evaluation 

分 类 号：R318[医药卫生—生物医学工程]