Endogenous hormones matters in evaluation of endocrine disruptive effects mediated by nuclear receptors  

作　　者：Yanbin Zhao Karl Fent 

机构地区：[1]State Environmental Protection Key Laboratory of Environmental Health Impact Assessment of Emerging Contaminants,School of Environmental Science and Engineering,Shanghai Jiao Tong University,800 Dongchuan Road,Shanghai 200240,China [2]ETH Zürich,Institute of Biogeochemistry and Pollution Dynamics,Department of Environmental Systems Science,CH-8092 Zürich,Switzerland

出　　处：《Eco-Environment & Health》2024年第3期257-259,共3页生态环境与健康（英文）

基　　金：supported by the National Natural Science Foundation of China(22122605);the National Key Research and Development Program of China(2022YFC3902100).

摘　　要：In recent decades,endocrine-disrupting chemicals(EDCs)have emerged as a prominent focus on environmental science and policy.Notably,extensive use of in vitro bioassays founded on ligand-receptor binding has facilitated the identification of a substantial number of potential EDCs,particularly agonists/antagonists of nuclear receptors such as estrogen receptors and thyroid hormone receptors[1].These datasets have significantly augmented the discovery of potential EDCs.However,when subjecting these compounds to in vivo exposures,spanning from teleost fish to rodents and humans,observations frequently deviated from in vitro anticipation[2,3].This discrepancy and the apparent lack of prognostic value are shared with the difficulties of in vitro-in vivo extrapolations in classical toxicological endpoints.While the utility of in vitro identification is without doubt,its potential EDCs require in vivo confirmation.The resulting complexity in EDCs outcomes,nevertheless,has not yet received adequate attention and thorough interpretation.

关 键 词：DOUBT CONFIRMATION IDENTIFICATION 

分 类 号：R58[医药卫生—内分泌]