尪痹片联合洛索洛芬钠治疗类风湿关节炎的临床研究  

Clinical study on Wangbi Capsules combined with Loxoprofen Sodium Tablets in treatment of rheumatoid arthritis

作　　者：毛建杰[1] 葛文杰[1] 蔡建平[1] 王庆[1] MAO Jianjie;GE Wenjie;CAI Jianping;WANG Qing(Department of Joint orthopedics,Wuxi Hospital of Traditional Chinese Medicine,Wuxi 214000,China)

机构地区：[1]无锡市中医医院关节骨科,江苏无锡214000

出　　处：《现代药物与临床》2024年第9期2389-2393,共5页Drugs & Clinic

基　　金：无锡市卫生健康委科研项目(Q201916)。

摘　　要：目的 观察尪痹片联合洛索洛芬钠片治疗类风湿关节炎的治疗效果。方法 选取无锡市中医医院2021年1月—2023年1月101例类风湿性关节炎患者,采用随机数字表+密封信法将所有患者分成对照组(51例)和治疗组(50例)。对照组口服洛索洛芬钠片,1片/次,3次/d。治疗组在此基础上口服尪痹片,4片/次,3次/d。两组连续治疗3个月。比较两组临床疗效、关节压痛、肿胀个数、免疫指标、血清因子和血清炎症因子。结果 经过治疗,治疗组患者的总有效率(96.00%)较对照组(82.35%)更高(P<0.05)。经过治疗,两组关节压痛、肿胀个数均减少(P<0.05);治疗组关节压痛、肿胀个数少于对照组(P<0.05)。经过治疗,两组外周血辅助性T细胞17(Th17)、Th17/Treg比值、红细胞沉降率(ESR)、血清C-反应蛋白(CRP)、类风湿因子(RF)、抗环瓜氨酸多肽抗体(anti-CCP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平均降低,调节性T细胞(Treg)均升高(P<0.05);治疗组外周血Th17、Th17/Treg、ESR、血清CRP、RF、anti-CCP、IL-6、TNF-α水平低于对照组,Treg高于对照组(P<0.05)。结论 尪痹片联合洛索洛芬钠片治疗类风湿关节炎的效果良好,可有效减少关节压痛和肿胀,改善免疫功能和炎症反应。Objective To observe the therapeutic effect of Wangbi Capsules combined with Loxoprofen Sodium Tablets in treatment of rheumatoid arthritis.Methods A total of 101 patients with rheumatoid arthritis in Wuxi Hospital of Traditional Chinese Medicine from January 2021 to January 2023 were selected,and were divided into a control group(51 cases)and a treatment group(50 cases)using a random number table and sealed letter method.Patients of the control group orally took Loxoprofen Sodium Tablets,1 tablets/time,3 times daily.On this basis,patients in the treatment group orally took Wangbi Capsules,4 tablets/time,3 times daily.Patients of two groups were treated for 3 months.The clinical efficacy,joint tenderness,number of swelling,immune indicators,serum factors,and serum inflammatory factors were compared between two groups.Results After treatment,the total effective rate(96.00%)of the treatment group was higher than 82.35%of the control group(P<0.05).After treatment,the number of joint tenderness and swelling in both groups decreased(P<0.05),and the number ofjoint tenderness and swelling in the treatment group was less than that in the control group(P<0.05).After treatment,peripheral blood T helper cell 17(Th17),Th17/Treg ratio,ESR,levels of serum CRP,RF,anti-CCP,IL-6,and TNF-αin both groups were decreased,while regulatory T cells(Treg)were increased(P<0.05).The peripheral blood Th17,Th17/Treg ratio,ESR,levels of serum CRP,RF,anti-CCP,IL-6,and TNF-αin the treatment group were lower than those in the control group,while Treg levels were higher than those in the control group(P<0.05).Conclusion The combination of Wangbi Capsules and Loxoprofen Sodium Tablets has shown good efficacy in treating rheumatoid arthritis,effectively reducing joint tenderness and swelling,and improving immune function and inflammatory response.

关 键 词：尪痹片 洛索洛芬钠片 类风湿关节炎 辅助性T细胞17 红细胞沉降率 C-反应蛋白 肿瘤坏死因子-α 

分 类 号：R982[医药卫生—药品]