苦参碱治疗皮肤病的药理作用研究进展  

Research progress on pharmacological effects of matrine in treatment of skin diseases

作　　者：赵一骋 杨素清[2] 周佳静 ZHAO Yicheng;YANG Suqing;ZHOU Jiajing(Heilongjiang University of Traditional Chinese Medicine,Harbin 150040,China;Department of Dermatology,First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine,Harbin 150040,China;Department of Dermatology,Yantai Traditional Chinese Medicine Hospital,Yantai 264000,China)

机构地区：[1]黑龙江中医药大学,黑龙江哈尔滨150040 [2]黑龙江中医药大学附属第一医院皮肤科,黑龙江哈尔滨150040 [3]烟台市中医医院皮肤科,山东烟台264000

出　　处：《现代药物与临床》2024年第9期2437-2442,共6页Drugs & Clinic

基　　金：国家自然科学基金资助项目(81973846)。

摘　　要：皮肤病可引起不同程度的瘙痒、疼痛,影响美观,还严重影响患者的生活质量。苦参碱是苦参中提取的生物碱,具有多种药理作用,可通过调节免疫反应、减轻炎症损伤、增强细胞自噬、促进细胞凋亡、镇痛止痒、抗皮肤纤维化等多途径、多靶点对多种皮肤病发挥治疗作用。总结了苦参碱治疗皮肤疾病的药理作用研究进展,为苦参碱的临床应用提供参考。Skin diseases can cause varying degrees of itching,pain,affect aesthetics,and seriously affect the quality of life of patients.Matrine is an alkaloid from Sophorae Flavescentis Radix,which has various pharmacological effects.Matrine can treat various skin diseases through multiple pathways and targets,such as regulating immune response,reducing inflammatory damage,enhancing cell autophagy,promoting cell apoptosis,relieving pain and itching,and resisting skin fibrosis.This article summarizes the pharmacological research progress of matrine in treatment of skin diseases,providing reference for the clinical application of matrine.

关 键 词：苦参碱 皮肤病 免疫反应 炎症损伤 细胞自噬 细胞凋亡 镇痛止痒 皮肤纤维化 

分 类 号：R986[医药卫生—药品]