木犀草素防治急性肺损伤的药理作用研究进展  

Research progress on pharmacological effects of luteolin in prevention and treatment of acute lung injury

作　　者：张文 姚晓燕[1] 周文慧[1] 夏坤 王翰洲 王敏[1] 李光熙[1] ZHANG Wen;YAO Xiaoyan;ZHOU Wenhui;XIA Kun;WANG Hanzhou;WANG Min;LI Guangxi(Department of Respiration,Guang'anmen Hospital,Chinese Academy of Traditional Chinese Medicine,Beijing 100053,China)

机构地区：[1]中国中医科学院广安门医院呼吸科,北京100053

出　　处：《现代药物与临床》2024年第9期2448-2452,共5页Drugs & Clinic

基　　金：中央高水平中医医院临床研究和成果转化能力提升项目(HLCMHPP20230;HLCMHPP2023092)。

摘　　要：急性肺损伤是一种急性炎症性肺部疾病,严重者可发生急性呼吸衰竭。临床治疗急性肺损伤主要控制炎症反应和改善临床症状。木犀草素是一种天然的黄酮类化合物,具有多种生物学作用,可通过降低炎症反应、降低氧化应激反应、抑制细胞凋亡、改善肺上皮离子转运功能发挥防治急性肺损伤的作用。总结了木犀草素防治急性肺损伤的药理作用研究进展,为木犀草素的临床应用提供参考。Acute lung injury is an acute inflammatory lung disease,and severe cases can lead to acute respiratory failure.The clinical treatment of acute lung injury mainly controls inflammatory response and improves clinical symptoms.Luteolin is a natural flavonoid compound with multiple biological functions.Luteolin can prevent and treat acute lung injury by reducing inflammation,oxidative stress,cell apoptosis,and improving the ion transport function of lung epithelium.This article summarizes the pharmacological research progress of luteolin in prevention and treatment of acute lung injury,providing reference for the clinical application of luteolin.

关 键 词：木犀草素 急性肺损伤 炎症反应 氧化应激反应 细胞凋亡 离子转运功能 

分 类 号：R974[医药卫生—药品]