不同FEV_(1)的支气管扩张症患者气道炎症与肺功能损害的相关性及肺功能受损的影响因素分析  

Correlation between Airway Inflammation and Lung Function Impairment in Patients with Bronchiectasis with Different FEV_(1) and Analysis of Influencing Factors of Lung Function Impairment

作　　者：黄霞 古丽茹·阿热斯兰 冯梅 娜迪热·阿不都萨拉木 李媛媛 张佩佩 苏东栋 HUANG Xia;Guliru·Aresilan;FENG Mei;Nadire·Abudousalamu;LI Yuan-yuan;ZHANG Pei-pei;SU Dong-dong(Department of Respiratory and Critical Care Medicine,Xinjiang Uygur Autonomous Region Infectious Diseases Hospital,Urumqi,Xinjiang,830000,China;Department of TuberculosisⅢXinjiang Uygur Autonomous Region Infectious Diseases Hospital,Urumqi,Xinjiang,830000,China)

机构地区：[1]新疆维吾尔自治区传染病医院呼吸与危重症医学科,新疆乌鲁木齐830000 [2]新疆维吾尔自治区传染病医院结核三科,新疆乌鲁木齐830000

出　　处：《现代生物医学进展》2024年第18期3447-3451,共5页Progress in Modern Biomedicine

基　　金：新疆维吾尔自治区自然科学基金项目(2020D01A108);新疆医科大学第八附属医院科研项目(202208)。

摘　　要：目的:本研究旨在探讨不同FEV_(1)的支气管扩张症患者气道炎症与肺功能损害的相关性及肺功能受损的影响因素分析。方法:选取2022年5月至2024年1月期间在本院呼吸内科收治的80例支气管扩张症患者作为研究对象,分析各组一般资料,对比各组肺功能、气道炎性细胞因子水平,采用Pearson直线分析法分析结果显示支气管扩张症患者肺功能与气道炎症的关系,采用多因素Logisitic回归分析支气管扩张症患者肺功能受损的影响因素。结果:将三组的FVC、FEV_(1)/FVC、DLCO评估纳入研究并实施组间差异性比较,结果显示,高FEV_(1)组、中FEV_(1)组FVC、FEV_(1)/FVC、FVC高于低FEV_(1)组,高FEV_(1)组FVC、FEV_(1)/FVC、FVC高于中FEV_(1)组(P<0.05)。将三组的ESR、CRP、WBC、NEUT、PCT、IL-4、IL-6、IL-10、TNF-α水平评估纳入研究并实施组间差异性比较,结果显示,高FEV_(1)组、中FEV_(1)组ESR、CRP、WBC、NEUT、PCT、IL-4、IL-6、TNF-α水平低于低FEV_(1)组,IL-10水平高于低FEV_(1)组(P<0.05);高FEV_(1)组ESR、CRP、WBC、NEUT、PCT、IL-4、IL-6、TNF-α水平低于中FEV_(1)组,IL-10水平高于中FEV_(1)组(P<0.05)。采用Pearson直线分析法分析结果显示,支气管扩张症患者FEV_(1)、FVC、FEV_(1)/FVC、DLCO与气道炎症因子ESR、CRP、WBC、NEUT、PCT、IL-4、IL-6、TNF-α均呈正相关,与IL-10呈负相关(P<0.001)。自变量设置为上述资料中对比有差异的指标包括FVC、FEV_(1)/FVC、DLCO、ESR、CRP、WBC、NEUT、PCT、IL-4、IL-6、IL-10、TNF-α,因变量为支气管扩张症患者肺功能受损,进行多因素Logisitic回归分析,结果显示,支气管扩张症患者肺功能受损的影响因素是FVC、FEV_(1)/FVC、DLCO、ESR、CRP、WBC、NEUT、PCT、IL-4、IL-6、IL-10、TNF-α。结论:气道炎症随支气管扩张症患者FEV_(1)水平升高而升高,其与肺功能密切相关,且是肺功能受损的影响因素。Objective:This study was to investigate the correlation between airway inflammation and lung function impairment in patients with bronchiectasis with different FEV_(1) and to analyze the influencing factors of lung function impairment.Methods:80 patients with bronchiectasis admitted to the respiratory department of our hospital from May 2022 to January 2024 were selected as research objects.General data of each group were analyzed,and lung function and airway inflammatory cytokine levels were compared in each group.Pearson linear analysis was used to analyze the relationship between lung function and airway inflammation in patients with bronchiectasis,and multi-factor Logisitic regression was used to analyze the influencing factors of lung function impairment in patients with bronchiectasis.Results:The FVC,FEV_(1)/FVC and DLCO evaluation of the three groups were included in the study and the difference among the groups was compared.The results showed that the FVC,FEV_(1)/FVC and FVC of the high FEV_(1) group and the medium FEV_(1) group were higher than those of the low FEV_(1) group.FVC,FEV_(1)/FVC and FVC in high FEV_(1)1 group were higher than those in medium FEV_(1) group(P<0.05).The levels of ESR,CRP,WBC,NEUT,PCT,IL-4,IL-6,IL-10 and TNF-αin the three groups were included in the study and the differences between the groups were compared.The levels of ESR,CRP,WBC,NEUT,PCT,IL-4,IL-6 and TNF-αin high and medium FEV_(1) groups were lower than those in low FEV_(1) group,and the levels of IL-10 were higher than those in low FEV_(1) group(P<0.05).The levels of ESR,CRP,WBC,NEUT,PCT,IL-4,IL-6 and TNF-αin high FEV_(1) group were lower than those in medium FEV_(1) group,and the levels of IL-10 were higher than those in medium FEV_(1) group(P<0.05).The results of Pearson linear analysis showed that FEV_(1),FVC,FEV_(1)/FVC and DLCO were positively correlated with airway inflammatory factors ESR,CRP,WBC,NEUT,PCT,IL-4,IL-6 and TNF-α,and negatively correlated with IL-10 in patients with bronchiectasis(P<0.05).Independent

关 键 词：支气管扩张症 气道炎症 肺功能 受损 

分 类 号：R562.22[医药卫生—呼吸系统]