盐酸氨溴索联合呼吸操肌力训练对老年COPD稳定期患者肺功能、呼吸肌肌力及血清HMGB1、TGF-β1、SAA水平的影响  

Effects of Ambroxol Hydrochloride Combined with Respiratory Muscle Strength Training on Lung Function,Respiratory Muscle Strength and Serum HMGB1,TGF-β1 and SAA Levels in Elderly Patients with Stable Stage COPD

作　　者：于庆丰 季小玲 张兆岩 苏莉 范艳秋 惠娟 YU Qing-feng;JI Xiao-ling;ZHANG Zhao-yan;SU Li;FAN Yan-qiu;HUI Juan(First Department of Cadre Ward,960th Hospital of Joint Logistics Support Force of PLA,Jinan,Shandong,250031,China;Department of Respiratory,Jinan Fifth Peoples Hospital,Jinan,Shandong,250022,China)

机构地区：[1]解放军联勤保障部队第九六〇医院干部病房一科,山东济南250031 [2]济南市第五人民医院呼吸内科,山东济南250022

出　　处：《现代生物医学进展》2024年第18期3456-3459,共4页Progress in Modern Biomedicine

基　　金：军队保健专项科研课题(22BJ248)。

摘　　要：目的:探讨盐酸氨溴索联合呼吸操肌力训练对老年慢性阻塞性肺部疾病(COPD)稳定期患者肺功能、呼吸肌肌力及血清高迁移率族蛋白1(HMGB1)、转化生子因子-β1(TGF-β1)、淀粉样蛋白A(SAA)水平的影响。方法:采用随机数字表法将我院2021年3月~2023年4月期间收治的123例老年COPD稳定期患者分为对照组(盐酸氨溴索治疗,61例)和观察组(盐酸氨溴索联合呼吸操肌力训练,62例)。对比两组疗效、肺功能、呼吸肌肌力及血清HMGB1、TGF-β1、SAA水平和不良反应。结果:对照组临床总有效率为78.69%,观察组的为93.55%,后者明显更高(P<0.05)。与对照组相比,观察组干预2个月后第1秒用力呼气容积(FEV_(1))、用力肺活量(FVC)、FEV_(1)/FVC、最大呼气压(MEP)、最大吸气压(MIP)更高,HMGB1、TGF-β1、SAA水平更低(P<0.05)。两组不良反应发生率对比未见差异(P>0.05)。结论:盐酸氨溴索联合呼吸操肌力训练治疗老年COPD稳定期患者,可有效提高临床治疗效果,改善患者的肺功能、呼吸肌肌力,同时调节血清HMGB1、TGF-β1、SAA水平。Objective:To observe the effects of ambroxol hydrochloride combined with respiratory muscle strength training on lung function,respiratory muscle strength and serum levels of high mobility group protein 1(HMGB1),transforming growth factor-β1(TGF-β1)and serum amyloid A(SAA)in elderly patients with stable stage chronic obstructive pulmonary disease(COPD).Methods:123 elderly patients with stable stage COPD admitted to our hospital from March 2021 to April 2023 were divided into control group(ambroxol hydrochloride treatment,61 cases)and observation group(ambroxol hydrochloride combined with respiratory muscle strength training,62 cases)by random number table method.The efficacy,lung function,respiratory muscle strength,serum HMGB1,TGF-β1,SAA levels and adverse reactions were compared between two groups.Results:Compared with the control group of 78.69%,the clinical total effective rate of the observation group further increased by 93.55%(P<0.05).Compared with control group,the forced expiratory volume in the first second(FEV_(1)),forced vital capacity(FVC),FEV_(1)/FVC,maximum expiratory pressure(MEP)and maximum inspiratory pressure(MIP)were higher in observation group at 2 months after intervention,and HMGB1,TGF-β1,and SAA were lower(P<0.05).There was no difference in the incidence of adverse reactions between two groups(P>0.05).Conclusion:Ambroxol hydrochloride combined with respiratory muscle strength training in the treatment of elderly patients with stable stage COPD,which can effectively improve the clinical treatment effect,improve the lung function and respiratory muscle strength of patients,and regulate the levels of serum HMGB1,TGF-β1 and SAA without increasing the incidence of adverse reactions.

关 键 词：呼吸操肌力训练 盐酸氨溴索 老年 稳定期 慢性阻塞性肺部疾病 肺功能 呼吸肌肌力 HMGB1 TGF-β1 SAA 

分 类 号：R563[医药卫生—呼吸系统]