甲型流感病毒性肺炎血清PDCD5、CXCL8、YKL-40与病情和临床转归的关系研究  

Study on the Relationship between Serum PDCD5,CXCL8,YKL-40 and the Disease Condition and Clinical Outcomeof Influenza A Virus Pneumonia

作　　者：梁晗 于莉莉[1] 邵冰[3] 李锦 于淳 LIANG Han;YU Li-li;SHAO Bing;LI Jin;YU Chun(School of Basic Medical Sciences of Xinxiang Medical University,Xinxiang,Henan,453000,China;Department of Infectious Diseases,Jilin Fifth People's Hospital,Jilin,Jilin,132002,China;Basic Teaching and Research Office of Jilin Medical University,Jilin,Jilin,132002,China;Department of Infectious Diseases,Changchun Infectious Disease Hospital,Changchun,Jilin,132001,China;Department of Emergency,Jilin 465 Hospital,Jilin,Jilin,132002,China)

机构地区：[1]新乡医学院基础医学院,河南新乡453000 [2]吉林市第五人民医院感染科,吉林吉林132002 [3]吉林医药学院基础教研室,吉林吉林132002 [4]长春市传染病医院感染科,吉林长春132001 [5]吉林市四六五医院急诊科,吉林吉林132002

出　　处：《现代生物医学进展》2024年第18期3485-3489,3441,共6页Progress in Modern Biomedicine

基　　金：河南省自然科学基金项目(162300410225);国家自然科学基金项目(81500675)。

摘　　要：目的:研究探讨甲型流感病毒性肺炎血清程序化细胞死亡分子5(PDCD5)、CXC趋化因子配体8(CXCL8)、人类软骨糖蛋白39(YKL-40)与病情和临床转归的关系。方法:选取2021年3月~2023年5月吉林市第五人民医院收治的165例甲型流感病毒性肺炎患者为对象纳入观察组,另选同期进行健康体检的健康受试者50例纳入对照组。对患者及受试者的PDCD5、CXCL8、YKL-40进行检测,比较组间各指标水平差异性,并对比不同病情甲型流感病毒性肺炎患者各项指标水平。统计患者临床转归情况,将患者分为死亡组和生存组,对比两组间PDCD5、CXCL8、YKL-40水平,并采用单因素和多因素Logistic分析甲型流感病毒性肺炎患者死亡的危险因素和保护因素。结果:观察组PDCD5、CXCL8、YKL-40水平高于对照组(P<0.05)。重症组PDCD5、CXCL8、YKL-40水平高于轻症组(P<0.05)。经随访观察,有39例患者出现死亡,死亡组PDCD5、CXCL8、YKL-40水平高于生存组(P<0.05)。经单因素分析显示,两组患者性别、体质指数(BMI)、吸烟史、饮酒史、高血压病史、糖尿病史、高脂血病史、病程比较无统计学差异性(P>0.05),而死亡组年龄、PDCD5、CXCL8、YKL-40高于生存组,用力肺活量(FVC)、呼气峰流量(PEF)、最大呼气中段流量(MMEF)低于生存组(P<0.05)。经Logistic多因素分析,年龄、PDCD5、CXCL8、YKL-40升高是甲型流感病毒性肺炎患者预后转归的独立危险因素,FVC、PEF、MMEF是患者预后转归的保护因素。结论:血清PDCD5、CXCL8、YKL-40参与甲型流感病毒性肺炎的发生和病情进展过程,并与患者的临床转归密切相关,与年龄一起构成患者预后转归的危险因素,而FVC、PEF、MMEF是患者转归的保护因素。Objective:To investigate the relationship between serum programmed cell death molecule 5(PDCD5),CXC chemokine ligand 8(CXCL8),human cartilage glycoprotein 39(YKL-4O)and disease condition and clinical outcome in influenza A virus pneumonia.Methods:165 patients with influenza A virus pneumonia who were admitted to Jilin Fifth People's Hospital from March 2021 to May 2023 were selected as observation group,and 50 healthy subjects who underwent physical examination during the same period were selected as control group.The PDCD5,CXCL8 and YKL-40 of patients and subjects were detected,and the differences of each index level between groups were compared,and the levels of each index of patients with influenza A virus pneumonia in different conditions were compared.The clinical outcomes of patients were statistically analyzed,and patients were divided into death group and survival group,the levels of PDCD5,CXCL8 and YKL-40 were compared between two groups,the risk factors and protective factors of death in patients with influenza A virus pneumonia were analyzed by univariate and multivariate Logistic analysis.Results:The levels of PDCD5,CXCL8 and YKL-40 in observation group were higher than those in control group(P<0.05).The levels of PDCD5,CXCL8 and YKL-40 in severe group were higher than those in mild group(P<0.05).After follow-up observation,39 patients died,and the levels of PDCD5,CXCL8 and YKL-40 in death group were higher than those in survival group(P<0.05).Univariate analysis showed that,there was no significant difference in gender,body mass index(BMI),smoking history,drinking history,hypertension history,diabetes history,hyperlipidemia history and course of disease between two groups(P>0.05).The age,PDCD5,CXCL8 and YKL-40 in death group were higher than those in survival group,and the forced vital capacity(FVC),peak expiratory flow(PEF)and maximum middle expiratory flow rate(MMEF)were lower than those in survival group(P<0.05).Logistic multivariate analysis showed that,age,PDCD5,CXCL8 and YKL-40 were independent

关 键 词：甲型流感病毒性肺炎 PDCD5 CXCL8 YKL-40 临床转归 影响因素 

分 类 号：R563.14[医药卫生—呼吸系统]