Unlocking the potential of transdermal drug delivery  

作　　者：Shuang Li Jianhao Wu Xiangjun Peng Xi-Qiao Feng 

机构地区：[1]Institute of Biomechanics and Medical Engineering,Applied Mechanics Laboratory,Department of Engineering Mechanics,Tsinghua University,Beijing,China

出　　处：《International Journal of Smart and Nano Materials》2024年第3期432-468,共37页国际智能和纳米材料杂志（英文）

基　　金：supported by the National Natural Science Foundation of China [12032014,11921002].

摘　　要：Transdermal drug delivery(TDD)has gained clinical approval over several decades,with extensive research dedicated to novel drug and device development.Despite notable research progress,the mar-ket adoption of TDD devices has not met anticipated levels,with oral administration and injection remaining predominant delivery meth-ods.To maximize the potential of TDD,we identify bottlenecks hinder-ing its widespread clinical application and propose promising research avenues.We begin by analyzing stringent demands necessary to truly benefit patients,addressing significant challenges in biomechanics,nanomedicine,and flexible electronics.Subsequently,we delve into skin anatomy,enhancement strategies,nano-carriers,and their under-lining mechanisms,highlighting the importance and framework of quantitative modeling.Based on these discussions,we highlight the core strength of TDD,such as automatic precise administration based on feedback and high delivery efficiencies,especially applicable to localized conditions(e.g.,central nervous system diseases,tumors).Finally,we envision the future of intelligent TDD device and its opera-tion scenario,aiming to steer research efforts toward faster translation of laboratory innovations into widely used products for sufferers.

关 键 词：Transdermal drug delivery BIOMECHANICS NANOMEDICINE flexible electronics 

分 类 号：TB383[一般工业技术—材料科学与工程]