Synthesis and characterization of ultra-soft alginate hydrogel mimicking lung tissue  

作　　者：Xiangpeng Li Jihua Gou Chiranjit Maiti Olusegun J.Ilegbusi 

机构地区：[1]Department of Mechanical and Aerospace Engineering,University of Central Florida,Orlando,FL,USA

出　　处：《International Journal of Smart and Nano Materials》2024年第3期593-609,共17页国际智能和纳米材料杂志（英文）

基　　金：supported by the UCF Seed Funding Program−Exploratory Research Award and the US National Science Foundation CBET Nanoscale Interactions Program [Award No.2153814].

摘　　要：Alginate hydrogels possess properties analogous to those of the extracellular matrix(ECM).Thus,their mechanical behavior approx-imates soft tissue,which makes them desirable for the production of tissue-equivalent soft deformable structures.This study aims to determine the synthesis-structure-property relationship for alginate hydrogel with the Young’s modulus in the range of 10°~101 kPa,mimicking to that of human lung tissue.Hydrogels,a 3D polymer network embedded in a water-rich environment.Homogeneous alginate hydrogels are synthesized by a direct mixture of sodium alginate and CaCO3,followed by the addition of D-glucono-δ-lactone(GDL)to initiate in-situ Ca^(2+)release and gelation.The influence of alginate concentration and molar ratio of the constitu-ent calcium ion to carboxyl group from alginate monomer are evaluated while the Young’s modulus of the hydrogel is carefully controlled within the desired range.FTIR and SEM are used to characterize the influence of synthesis parameters at the molecular and microstructure levels.Tension and compression testing are performed to determine the Young’s modulus of the material.Empirical relations are established between synthesis parameters and the mechanical property.The result of the study will be subse-quently used to guide the additive manufacturing of soft deform-able structures based on alginate hydrogels.

关 键 词：ALGINATE HYDROGELS Ultra-low modulus lung tissue-mimicking materials 

分 类 号：O62[理学—有机化学]