Ferroelectric catalytic BaTiO_(3)-based composite insoles to promote healing of infected wounds:Analysis of antibacterial efficacy and angiogenesis  

作　　者：Qiong Liu Xudan Liu Linfeng Fan Xinna Bai Hao Pan Hang Luo Dou Zhang Haitao Huang Chris R.Bowen 

机构地区：[1]State Key Laboratory of Powder Metallurgy,Central South University,Changsha,Hunan,China [2]Department of Applied Physics,The Hong Kong Polytechnic University,Hong Kong,China [3]Department of Periodontics,Hunan Key Laboratory of Oral Health Research&Hunan 3D Printing Engineering Research Center of Oral Care&Hunan Clinical Research Center of Oral Major Diseases and Oral Health&Xiangya Stomatological Hospital&Xiangya School of Stomatology,Central South University,Changsha,Hunan,China [4]Department of Mechanical Engineering,University of Bath,Bath,UK

出　　处：《Interdisciplinary Materials》2024年第5期757-774,共18页交叉学科材料（英文）

基　　金：National Natural Science Foundation of China,Grant/Award Numbers:52172265,5230130435;Scientific research project of Hunan Provincial Department of Education,Grant/Award Number:21B0009;Hunan Excellent Youth Science Foundation,Grant/Award Number:2022JJ20067;State Key Laboratory of Powder Metallurgy,Central South University,Changsha,China;the Hong Kong Polytechnic University,Grant/Award Number:1-W34B。

摘　　要：Our feet are often subjected to moist and warm environments,which can promote the growth of harmful bacteria and the development of severe infection in wounds located in the foot.As a result,there is a need for new and innovative strategies to safely sterilize feet,when shoes are worn,to prevent any potential foot-related diseases.In this paper,we have produced a non-destructive,biocompatible and convenient-to-use insole by embedding a BaTiO_(3)(BT)ferroel ectric material into a conventional polydimethylsilane(PDMS)insole material to exploit a ferroelectric catalytic effect to promote the antibacterial and healing of infected wounds via the ferroelectric charges generated during walking.The formation of reactive oxygen species generated through a ferroelectric catalytic effect in the PDMS-BT composite is shown to increase the oxidative stress on bacteria and decrease both the activity of bacteria and the rate of formation of bacterial biofilms.In addition,the ferroelectric field generated by the PDMS-BT insole can enhance the level of transforming growth factor-beta and CD31 by influencing the endogenous electric field of a wound,thereby promoting the proliferation,differentiation of fibroblasts and angiogenesis.This work therefore provides a new route for antimicrobial and tissue reconstruction by integrating a ferroelectric biomaterial into a shoe insole,with significant potential for health-related applications.

关 键 词：ferroelectric filed effect PDMS-BaTiO3 insole piezo-catalysis wound healing 

分 类 号：R318[医药卫生—生物医学工程]