新型邻吡唑甲酰胺基苯甲酰胺化合物设计、合成与生物活性研究  

Design, synthesis and biological activities of a novel o-pyrazole formamidobenzamide derivative

作　　者：唐蜜 刘少华 周红生 李娟 周玮 赵亮 TANG Mi;LIU Shao-hua;ZHOU Hong-sheng;LI Juan;ZHOU Wei;ZHAO Liang(North China Pharmaceutical Co.,Ltd.,Shijiazhuang 050015,China;Hebei Chengxin Co.,Ltd.,Shijiazhuang 051130,China;Hebei Innovation Center of Cyanide Derivatives Technology,Shijiazhuang 051130,China;Hebei Institute of Fine Chemical Industry Technology,Shijiazhuang 051130,China)

机构地区：[1]华北制药股份有限公司,河北石家庄050015 [2]河北诚信集团有限公司,河北石家庄051130 [3]河北省氰衍生物技术创新中心,河北石家庄051130 [4]河北省精细化学品产业技术研究院,河北石家庄051130

出　　处：《精细与专用化学品》2024年第10期32-35,54,共5页Fine and Specialty Chemicals

摘　　要：近年来,已经有多种具备广泛生物活性的邻吡唑甲酰胺基苯甲酰胺类杀虫剂被研制出来。为了开发高效、低毒和环境友好型绿色生态杀虫剂,以邻氨基苯甲酸和2-(3-氯-2-吡啶基)-5-氧代-3-吡唑烷羧酸乙酯为主要原料合成了一种新颖邻吡唑甲酰胺基苯甲酰胺化合物,并通过NMR和元素分析确认。初步的生物活性测定结果表明,该化合物对小菜蛾和甜菜夜蛾的生物活性在10mg/kg下均达到100%。In recent years, many o-pyrazole formamidobenzamide insecticides with extensive biological activities have been developed.In order to develop green insecticides with high bioactivity, low toxicity and environment friendly, a novel o-pyrazole formamidobenzamide derivative was synthesized with o-aminobenzoic acid and ethyl 2-(3-chloro-2-pyridyl)-5-oxo-3-pyrazolidane carboxylate as the main starting materials, which was confirmed by NMR and elemental analysis.Preliminary bioassay results showed that the bioactivity of the compound to both plutella xylostella and asparagus caterpillar reached 100% at 10mg/kg.

关 键 词：邻吡唑甲酰胺基苯甲酰胺 设计 合成 杀虫活性 

分 类 号：TQ453[化学工程—农药化工]