外周血Vaspin、cAMP/cGMP、HSP-70与老年高血压患者并发心血管损害关系研究  

Relationship between Peripheral Blood Vaspin,cAMP/cGMP,HSP- 70 and Cardiovascular Damage in Elderly Patients with Hypertension

作　　者：钦佩[1] 王辉 王乃梅[1] QIN Pei;WANG Hui;WANG Naimei(Department of Geriatrics,Chengde Central Hospital,Chengde 067000,Hebei,China)

机构地区：[1]承德市中心医院老年病科,河北承德067000

出　　处：《中国分子心脏病学杂志》2024年第4期6236-6241,共6页Molecular Cardiology of China

摘　　要：目的 探讨外周血丝氨酸蛋白酶抑制因子(Vaspin)、环磷酸腺苷(cAMP)/环磷酸鸟苷(cGMP)、热休克蛋白70(HSP-70)与老年高血压并发心血管损害(CVD)的关系。方法 选取2019年4月—2022年5月收治的110例老年高血压并发CVD患者(CVD组)、110例老年单纯高血压患者(高血压组)及同期进行体检的110例健康人群(对照组),比较各组一般资料、外周血Vaspin、cAMP/cGMP、HSP-70。采用logistic回归分析老年高血压并发CVD的相关影响因素,采用受试者操作特征(ROC)曲线及曲线下面积(AUC)分析Vaspin、cAMP/cGMP、HSP-70及三者联合评估老年高血压患者并发CVD的价值,采用RR分析不同Vaspin、cAMP/cGMP、HSP-70水平患者并发CVD的危险度。结果 CVD组舒张压、收缩压高于高血压组、对照组,病程长于高血压组(P均<0.05)。各组Vaspin、cAMP/cGMP比较:CVD组<高血压组<对照组,各组HSP-70比较:CVD组>高血压组>对照组,两两比较差异有统计学意义(P均<0.05)。Logistic回归分析显示收缩压、舒张压、病程、HSP-70是老年高血压患者并发CVD的独立危险因素,Vaspin、cAMP/cGMP是老年高血压患者并发CVD的独立保护因素(P均<0.05)。ROC曲线显示Vaspin、cAMP/cGMP、HSP-70联合评估老年高血压患者并发CVD的AUC为0.901;Vaspin、cAMP/cGMP、HSP-70高水平患者发生CVD的危险度是低水平患者的0.262、0.348、3.034倍(P均<0.05)。结论 Vaspin、cAMP/cGMP、HSP-70水平与老年高血压患者并发CVD有关,联合检测可作为预测并发CVD的可靠方案。Objective To investigate the relationship between peripheral blood visceral adipose serine protease inhibitor(Vaspin),cyclic adenosine monophosphate(cAMP)/cyclic guanosine monophosphate(cGMP),heat shock protein 70(HSP-70) and senile hypertension complicated with cardiovascular damage(CVD).Methods A total of 110 elderly patients with hypertension complicated with CVD(CVD group),110 elderly patients with simple hypertension(hypertension group) and 110 healthy controls(control group) from April 2019 to May 2022 were selected.General information,peripheral blood Vaspin,cAMP/cGMP,HSP-70 were compared,Logistic regression was used to analyze the related factors of hypertension complicated by CVD in the elderly,and receiver operating characteristic(ROC) curve and area under the curve(AUC) were used to analyze Vaspin,cAMP/cGMP,HSP-70 and combined evaluation value of concurrent CVD,and RR was used to analyze the risk of concurrent CVD in patients with different Vaspin,cAMP/cGMP,HSP-70 expression levels.Results The diastolic blood pressure and systolic blood pressure in the CVD group were higher than those in the hypertension group and the control group,and the disease duration in the CVD group was longer than that in the hypertension group(all P<0.05).HSP-70 comparison:CVD group > hypertension group > control group,the difference was statistically significant(all P< 0.05);Logistic analysis showed that systolic blood pressure,diastolic blood pressure,course of disease,and HSP-70 were independent risk factors for elderly hypertension complicated by CVD,Vaspin,cAMP/cGMP were independent protective factors for elderly hypertension complicated by CVD(all P<0.05);The ROC curve showed that the AUC of Vaspin,cAMP/cGMP,HSP-70 combined to evaluate elderly hypertension complicated with CVD was 0.901;the risk of CVD in patients with high levels of Vaspin,cAMP/cGMP,HSP-70 was 0.262,0.348,3.034 times higher than that in patients with low levels(allP< 0.05).Conclusion The levels of Vaspin,cAMP/cGMP and HSP-70 CVD are related to CVD in el

关 键 词：高血压 心血管损害 丝氨酸蛋白酶抑制因子 环磷酸腺苷 环磷酸鸟苷 热休克蛋白70 

分 类 号：R544.1[医药卫生—心血管疾病]