左氧氟沙星与地塞米松联合用于中耳炎的治疗效果研究  

A study of the efficacy of Levofloxacin combined with dexamethasone and Mison in the treatment of otitis media

作　　者：高梅华 Gao Meihua(Tengzhou Longquan Community Health Service Center,Zaozhuang,Shandong,277599,China)

机构地区：[1]滕州市龙泉社区卫生服务中心,山东枣庄277599

出　　处：《中国医学文摘（耳鼻咽喉科学）》2024年第5期130-133,共4页Chinese Medical Digest(Otorhinolaryngology)

摘　　要：目的研究中耳炎患者行左氧氟沙星^(+)地塞米松治疗的效果。方法选择我院2020年1月-2022年12月收治的73例中耳炎患者,“随机取样法”分单一组(左氧氟沙星,n=37)、联用组(左氧氟沙星^(+)地塞米松,n=36),两组疗效比较。结果用药前分析炎症程度、T细胞亚群无差异,用药后分析不良反应无差异,P>0.05;用药后较单一组,联用组IL-2、IL-4、IL-8、TNF-a值更低:CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)值更高,CD8^(+)值更低;联用组有效率(97.30%)高于单一组(83.33%),P<0.05。结论左氧氟沙星^(+)地塞米松治疗中耳炎患者可减缓炎症程度、改善T细胞亚群,增强疗效、减少副作用发生,值得推崇。Objective To study the effect of Levofloxacin and dexamethasone therapy on otitis media.Methods A total of 73 patients with otitis media were selected from January 2020 to December 2022.They were randomly divided into control group(N=37)and Levofloxacin group(N=36).The patients in the observation group were treated with Levofloxacin and dexamethasone,the curative effect of the two groups was compared.Results There was no difference in the degree of inflammation and T cell subsets before and after treatment,P>0.05.Compared with the control group,the levels of IL-2,IL-4,IL-8 and tnf-in the observation group were lower Cd3^(+),CD4^(+),CD4^(+)/CD8^(+)were higher and CD8^(+)was lower in the observation group(97.30%)than in the control group(83.33%),P<0.05.Conclusion The treatment of otitis media with Levofloxacin and dexamethasone can reduce the degree of inflammation,improve T lymphocyte subsets,enhance the therapeutic effectand reducethe sideeffects.

关 键 词：左氧氟沙星 地塞米松 中耳炎 炎症程度:临床疗效:不良反应 

分 类 号：R76[医药卫生—耳鼻咽喉科]