The neurobiology of targeted muscle reinnervation for post-amputation pain  

作　　者：Natalie Tanner Omri Ayalon 

机构地区：[1]Drexel University College of Medicine,Philadelphia,PA 19129,USA [2]Department of Orthopedic Surgery,NYU Langone Medical Center,New York,NY 10010,USA

出　　处：《Plastic and Aesthetic Research》2023年第1期501-512,共12页整形与美容研究（英文版）

摘　　要：Targeted muscle reinnervation(TMR)is a peripheral nerve procedure that can prevent and treat postamputation pain.The nerve transfer allows for organized nerve regeneration and repair after amputation surgery.The procedure can successfully prevent neuromas despite large size mismatches between the donor and recipient nerves.Here,we discuss the fundamentals of peripheral nerve injury and regeneration as it pertains to TMR.We propose axonal pruning to explain axon behavior when there are large size mismatches between transferred nerves.Given the increasing use of TMR for amputees,future studies should investigate the basic science of peripheral nerves in TMR.Advances in this field have the potential to significantly improve clinical outcomes for these patients.

关 键 词：Targeted muscle reinnervation peripheral nerve injury nerve regeneration axonal pruning 

分 类 号：S82[农业科学—畜牧学]