Research advancement of DNA-based intelligent hydrogels:Manufacture, characteristics, application of disease diagnosis and treatment  

作　　者：Zhe-Han Yang Jie Yin Lei Xin Yuanfang Li Yijie Huang Ruo Yuan Ying Zhuo 

机构地区：[1]Chongqing Key Laboratory of Catalysis and Functional Organic Molecules,College of Environment and Resources,Chongqing Technology and Business University,Chongqing 400067,China [2]Key Laboratory of Luminescence and Real-Time Analytic Chemistry(Southwest University),Ministry of Education,College of Chemistry and Chemical Engineering,Southwest University,Chongqing 400715,China

出　　处：《Chinese Chemical Letters》2024年第10期92-101,共10页中国化学快报（英文版）

基　　金：financially supported by the National Natural Science Foundation of China(No.21804014);the Natural Science Foundation of Chongqing Science&Technology Commission(No.2023jcyjA3529);the Science and Technology Research Program of Chongqing Municipal Education Commission(No.KJQN202200832);Construction of Graduate Joint Training Base of Chongqing Municipal Education Commission(No.yjd223005)。

摘　　要：DNA-based hydrogels are exceptional materials for biological applications because of their numerous advantages such as biodegradability,biocompatibility,hydrophilicity,super absorbency,porosity,and swelling.Among these advantages,the ability of DNA-based hydrogels to respond to specific physical and chemical triggers and undergo reversible phase transitions has garnered significant attention in the fields of disease diagnosis(biosensors)and treatment(drug delivery).This article focuses on the recent advancements in the research of DNA-based hydrogels and discusses the different types of these hydrogels,the synthetic methods,their unique properties,and their applications in biosensors and drug delivery.The types of DNA hydrogels are categorized based on their building blocks,and the process of synthesis as well as the unique characteristics of DNA-based hydrogels are described.Then,DNA-based responsive hydrogels utilized as intelligent materials for the development of biosensors are reviewed.Furthermore,this article also presents the current status of DNA-based responsive hydrogels in drug delivery for cancer treatment,wound healing,and other therapeutic applications.Ultimately,this paper discusses the current challenges in expanding the practical application of DNA-based hydrogels.

关 键 词：DNA-based hydrogel Intelligent hydrogel MANUFACTURE CHARACTERISTICS Diseasediagnosis and treatment 

分 类 号：R318.08[医药卫生—生物医学工程] TQ427.26[医药卫生—基础医学]