Multicomponent remote C(sp^(2))–H bond addition by Ru catalysis:An efficient access to the alkylarylation of 2H-imidazoles  

作　　者：Yi Luo Lin Dong 

机构地区：[1]Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province,Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology,West China School of Pharmacy,Sichuan University,Chengdu 610041,China

出　　处：《Chinese Chemical Letters》2024年第10期257-261,共5页中国化学快报（英文版）

基　　金：financial support from 111 Project B18035;“the Fundamental Research Funds for the Central Universities”。

摘　　要：Sequential C–H bond addition with two different coupling partners is a powerful method for the rapid and modular construction of complex molecules based on simple starting materials.Herein,an efficient ruthenium-catalysed multicomponent long-range C–H functionalization of 2H-imidazoles was developed.This protocol showed good substrate suitability and yielded alkyl arylation products with potential biological activity.

关 键 词：Remote C-H functionalization Multi-component reaction Ruthenium catalysis 2H-Imidazoles 

分 类 号：O621.251[理学—有机化学]