Cucurbit[8]uril-based non-covalent heterodimer realized NIR cell imaging through topological transformation from nanowire to nanorod  

作　　者：Jianqiu Li Yi Zhang Songen Liu Jie Niu Rong Zhang Yong Chen Yu Liu 

机构地区：[1]College of Chemistry,State Key Laboratory of Elemento-Organic Chemistry,Nankai University,Tianjin 300071,China

出　　处：《Chinese Chemical Letters》2024年第10期262-268,共7页中国化学快报（英文版）

基　　金：National Natural Science Foundation of China(Nos.22131008 and 21971127);the Fundamental Research Funds for the Central Universities;the Haihe Laboratory of Sustainable Chemical Transformations for financial support。

摘　　要：In recent years,multicolor cascade supramolecular assemblies with controllable topological morphology have become a research hotspot due to their wide application in light-emitting materials,cell imaging and other fields.Herein,several kinds of macrocycles including cucurbiturils,calixarene and cyclodextrins are used as building blocks to construct fluorescent assemblies with anthryl-conjugated phenylpyridine(G),wherein cucurbit[8]uril(CB[8])and G can form nanowires at a stoichiometric ratio of n:n through host-guest encapsulation to form a non-covalent heterodimer.Significantly,the macrocycle confinement effect drastically enhances the fluorescence emission of G and emission peak generated bathochromic shift from 500 nm to 600 nm.When the supramolecular polymer is further assembled with amphiphilic calix[4]arene(SC_(4)A8),the fluorescence emission of G?CB[8]further increases to 1.4 times,accompanied by the morphological transformation from linear structure to nanorod structure.Subsequently,a very small amount of dye Cy5 is added to the assembly solution as an energy receptor,and the negatively charged G?CB[8]@SC_(4)A8 system is regarded as an energy donor.The efficient energy transfer process enables near-infrared(NIR)emission at 675 nm with 71%energy transfer efficiency(ΦET)at a donor/receptor ratio of 100:1.Finally,the cascade supramolecular assembly has been successfully applied to targeted imaging in the nucleus of HeLa and A549 cancer cells.

关 键 词：Multivalent assemblies CUCURBITURIL Morphological transformation Targeted imaging 

分 类 号：TB383.1[一般工业技术—材料科学与工程] O657.3[理学—分析化学]