磷脂基微乳液的制备及其负载白藜芦醇的性能研究  

Preparation of phospholipid-based microemulsion and properties of loaded resveratrol

作　　者：贾宝通 常宽 Baotong Jia;Kuan Chang(School of Chemical&Material Engineering,Jiangnan University,Wuxi,Jiangsu 214122,China)

机构地区：[1]江南大学化学与材料工程学院,江苏无锡214122

出　　处：《日用化学工业（中英文）》2024年第10期1191-1200,共10页China Surfactant Detergent & Cosmetics

基　　金：江苏省双创博士计划资助项目(JSSCBS20210816)。

摘　　要：以2∶1的比例,将大豆磷脂和烷基糖苷羟丙基磺酸钠复配作为乳化剂制备O/W微乳液。通过拟三元相图法确定了最优配方:助表面活性剂为1,2-己二醇,油相为己二酸二丁酯,复配表面活性剂与助表面活性剂的质量比Km为1∶2,己二酸二丁酯在体系中的质量分数为8.00%,水添加量为60.00%,水中无机盐的浓度为0.1 mol/L。透射式电子显微镜显示该微乳液为球形,油滴均匀分布,粒径为15~25 nm。该体系对于白藜芦醇的最大负载量为(11.55±0.14)mg/mL,显示出良好的增溶效果。在1.00%白藜芦醇负载量下,微乳液展示出良好的稳定化效果,50℃保存28 d后的保留率为77.13%±0.51%,比未包裹的提升19.21%;在365 nm的紫外光照下保存32 h后的保留率为57.21%±0.32%,比未包裹的提升20.72%。白藜芦醇在该体系中24 h的经皮渗透量可达(461.12±35.01)μg/Cm^(2),对难溶性的多酚类化合物有着良好的促渗效果。An O/W microemulsion(ME)was prepared by compounding soybean phospholipids and alkylglycoside sodium hydroxypropyl sulfonate(APGSHS)as the emulsifiers in a 2∶1 ratio.The optimal formulation was determined by the ternary phase diagram method:1,2-hexanediol as the co-surfactant,dibutyl adipate as the oil phase,the mass ratio of the complex surfactant to the co-surfactant(Km)of 1∶2,the mass fraction of dibutyl adipate in the system of 8.00%,and the amount of water added of 60.00%,and the concentration of inorganic salts in the water of 0.1 mol/L.Transmission electron microscopy show that the microemulsion is spherical,with oil droplets uniformly distributed,and the particle size is 15-25 nm.The maximum loading of the system for resveratrol is(11.55±0.14)mg/mL,which shows a good solubilization effect.At 1.00%resveratrol loading,the microemulsion shows good stabilization effect,with a retention rate of 77.13%±0.51%after 28 days of storage at 50℃,which is 19.21%higher than that of the unwrapped one,and a retention rate of 57.21%±0.32%after 32 h of storage at 365 nm UV illumination,which is 20.72%higher than that of the unwrapped one.The transdermal permeation amount of resveratrol in this system is up to(461.12±35.01)μg/cm^(2)for 24 h,which has a good osmotic effect on insoluble polyphenolic compounds.

关 键 词：表面活性剂 微乳液 磷脂 拟三元相图 白藜芦醇 稳定性 

分 类 号：TQ658[化学工程—精细化工]