益智精油O/W型微乳液的制备及其性能研究  

Preparation and properties of O/W microemulsion of Alpinia oxyphylla Miq.essential oil

作　　者：谢小丽[1] 胡璇[1] 黄英 王凯[1] 王丹[1] 于福来[1] Xiaoli Xie;Xuan Hu;Ying Huang;Kai Wang;Dan Wang;Fulai Yu(Tropical Crops Genetic Resources Institute,Chinese Academy of Tropical Agricultural Sciences&Key Laboratory of Biology and Cultivation of Herb Medicine(Haikou),Ministry of Agriculture and Rural Affairs,P.R.China&Hainan Provincial Engineering Research Center for Tropical Medicinal Plants,Haikou,Hainan 571101,China)

机构地区：[1]中国热带农业科学院热带作物品种资源研究所农业农村部中药材生物学与栽培重点实验室海南省热带药用植物工程研究中心,海南海口571101

出　　处：《日用化学工业（中英文）》2024年第10期1201-1210,共10页China Surfactant Detergent & Cosmetics

基　　金：海南省自然科学基金项目(821QN0936);中国热带农业科学院基本科研业务费专项(1630032022008);2023年社会公益类科研机构改革专项经费(PZS2023013,PZS2023018);国家科技资源共享服务平台:国家热带植物种质资源库。

摘　　要：益智(Alpinia oxyphylla Miq.)提取物是一种天然的化妆品原料,可作为植物功能油使用。为了获得稳定的益智精油(AOEO)水包油型(O/W型)微乳液,本研究通过拟三元相图法构建含AOEO的O/W型微乳液,考察表面活性剂、助表面活性剂、Km(表面活性剂与助表面活性剂的质量比)以及其不同组分及比例对微乳液面积的影响,并测定微乳液的粒径、形貌、电导率、水溶性及稳定性等指标,探讨其表征与理化性能。结果得到益智精油O/W型微乳液的较优配方为:m(蓖麻油聚氧乙烯醚40(EL-40))∶m(1,2-丙二醇)∶m(AOEO)=10.5∶3.5∶6,水相的过渡点为60%(质量分数),平均粒径为(26.580±0.133)nm,多分散指数(PDI)为0.226±0.010,在透射电子显微镜(TEM)与数码生物显微镜(DBM)下微乳液呈球形或类球形,规整,无黏边,并具有良好的水溶性、离心稳定性、热稳定性及低温贮藏稳定性。结果表明以微乳液为载体可实现益智精油的纳米包覆,为益智精油在日化领域的开发与应用提供参考。Alpinia oxyphylla Miq.extract is a kind of natural cosmetic raw material,which can be used as plant functional oil.In order to obtain a stable O/W microemulsion of Alpinia oxyphylla Miq.essential oil(AOEO),the O/W microemulsion containing AOEO was constructed by pseudo ternary phase diagram method.The effects of surfactants,cosurfactants,Km(mass ratio of surfactant to cosurfactant),and their different components and ratios on the area of the microemulsion were investigated.The particle size,morphology,conductivity,water solubility and stability of the microemulsion were measured,and its characterization and physicochemical properties were discussed.The results show that the optimal formula of O/W microemulsion of AOEO is obtained as follows:m(castor oil polyoxyethylene ether 40(EL-40))∶m(1,2-propylene glycol)∶m(AOEO)=10.5∶3.5∶6,the transition point of O/W microemulsion is 60%(mass fraction).The average particle size of the O/W microemulsion is(26.580±0.133)nm,the polydispersion index(PDI)is 0.226±0.010,and the microemulsion is slightly spherical or quasi-spherical,regular,and without adhering edges under transmission electron microscopy(TEM)and digital biological microscopy(DBM).The microemulsion has good water solubility,centrifugal stability,thermal stability and low temperature storage stability.The results show that the nano-coating of AOEO can be realized by using microemulsion as carrier,which provides reference for the development and application of AOEO in daily chemical field.

关 键 词：益智精油 微乳液 拟三元相图 蓖麻油聚氧乙烯醚 O/W型 

分 类 号：TQ658[化学工程—精细化工]