二氧化碳点阵激光联合308nm准分子激光治疗白癜风患者的效果  

Effects of carbon dioxide lattice laser combined with 308 nm excimer laser in treatment of vitiligo

作　　者：骆焕 林山 LUO Huan;LIN Shan(Department of Dermatology of Zhumadian First People’s Hospital,Zhumadian 463000 Henan,China)

机构地区：[1]驻马店市第一人民医院皮肤科,河南驻马店463000

出　　处：《中国民康医学》2024年第20期52-54,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:观察二氧化碳点阵激光联合308 nm准分子激光治疗白癜风患者的效果。方法:回顾性分析2019年5月至2022年5月该院收治的72例白癜风患者的临床资料。按照治疗方法不同将其分为观察组和对照组各36例,对照组予以308 nm准分子激光治疗,观察组在对照组基础上联合二氧化碳点阵激光治疗。比较两组临床疗效、治疗前后疾病特异性指标[血清酪氨酸酶抗体IgM(TYR-IgM)、酪氨酸酶抗体IgG(TYR-IgG)]水平、白斑消退时间,以及不良反应发生率。结果:观察组治疗总有效率为97.22%(35/36),高于对照组的77.78%(28/36),差异有统计学意义(P<0.05);治疗后,两组血清TYR-IgM、TYR-IgG水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);观察组白斑消退95%、50%、30%的时间均短于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:二氧化碳点阵激光联合308 nm准分子激光治疗白癜风患者可提高治疗总有效率,缩短白斑消退时间,以及降低疾病特异性指标水平的效果优于单纯308 nm准分子激光治疗。Objective:To observe effects of carbon dioxide lattice laser combined with 308 nm excimer laser in treatment of vitiligo.Methods:The clinical data of 72 patients with vitiligo admitted to the hospital from May 2019 to May 2022 were retrospectively analyzed.According to different treatment methods,they were divided into observation group and control group,36 cases in each group.The control group was treated with 308 nm excimer laser,while the observation group was treated with carbon dioxide lattice laser on the basis of that of the control group.The clinical efficacy,the levels of disease-specific indicators[serum tyrosinase antibody IgM(TYR-IgM),tyrosinase antibody IgG(TYR-IgG)]levels before and after the treatment,the incidence of adverse reactions,and the vitiligo regression time were compared between the two groups.Results:The total effective rate of the observation group was 97.22%(35/36),which was higher than 77.78%(28/36)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of serum TYR-IgM and TYR-IgG in the two groups were lower than those before the treatment,those in the observation group were lower than vitiligo the control group,and the differences were statistically significant(P<0.05).The time of 95%,50%and 30%regression of vitiligo in the observation group was shorter than that in the control group,and the difference was statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Carbon dioxide lattice laser combined with 308 nm excimer laser in the treatment of the vitiligo patients can improve the total effective rate of treatment,shorten the vitiligo regression time,and reduce the levels of disease-specific indicators.Moreover,it is superior to simple 308 nm excimer laser treatment.

关 键 词：白癜风 二氧化碳点阵激光 308 nm准分子激光 白斑消退时间 酪氨酸酶抗体IgM 酪氨酸酶抗体IgG 不良反应 

分 类 号：R758.4[医药卫生—皮肤病学与性病学]