基于有效病例总结毛静远教授辨治室性期前收缩的用药规律  

Professor Mao Jingyuan′s Medication Characteristics for Treating Premature Ventricular Complex

作　　者：王慈 曹雅雯 张璇 李明伟 王贤良[1] 毛静远[1] WANG Ci;CAO Yawen;ZHANG Xuan;LI Mingwei;WANG Xianliang;MAO Jingyuan(First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,National Clinical Research Center of Chinese Medicine Acupuncture and Moxibustion,Tianjin 300381,China;Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China)

机构地区：[1]天津中医药大学第一附属医院,国家中医针灸临床医学研究中心,天津300381 [2]天津中医药大学,天津301617

出　　处：《中西医结合心脑血管病杂志》2024年第20期3667-3674,共8页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

基　　金：国家中医药传承创新团队项目-中医药防治心血管疾病传承创新团队(No.ZYYCXTD-C-202203);教育部创新团队发展计划项目(No.IRT-16R54);国家中医药行业科研专项(No.201407001-6A)。

摘　　要：目的:通过对毛静远教授治疗室性期前收缩的有效病例资料进行分析,总结其辨治室性期前收缩的组方用药规律。方法:收集2016年9月—2021年2月在天津中医药大学第一附属医院门诊确诊为室性期前收缩,经毛静远教授予中药治疗症状改善有效的病历资料,采用Microsoft Excel 2010建立“室性期前收缩病人信息数据库”,对病人基本资料、中医证型及处方用药等信息进行统计提取。采用R软件与SPSS软件,运用关联规则与聚类分析方法挖掘毛静远教授辨治室性期前收缩的配伍用药特点。结果:共计纳入治疗有效的室性期前收缩病人98例,包括男44例,女54例,年龄(58.12±13.72)岁。病人证型以阴虚血瘀、痰热血瘀、痰瘀互结为主,虚性证素主要为阴虚、阳虚、气虚,实性证素包括血瘀、痰、火(热)。用药涉及104味,以熟地黄、丹参、全蝎、陈皮为基础,临证加以化裁施治。结论:毛静远教授认为室性期前收缩病人多虚多瘀,其论治室性期前收缩以养阴息风、化瘀通络为主要思路,临床治疗以熟地黄、全蝎、丹参、陈皮为核心处方,并依据具体证型辨证化裁用药。Objective:To summarize the prescription and medication rules for treating premature ventricular comple(PVC)by Professor Mao Jingyuan.Methods:The valid medical records of PVC patients diagnosed by Professor Mao and treated with Chinese medicine were selected.Microsoft Excel 2010 was used to establish a comprehensive"PVC Patient Information Database"for the systematic extraction of patients′basic information,traditional Chinese medicine syndrome types,and prescription medication details.The medication and compatibility characteristics of Professor Mao for treating PVC were explored by association rules and cluster analysis methods in R and SPSS software.Results:A total of 98 patients with PVC were included,including 44 males and 54 females,with an average age of(58.12±13.72)years old was used.The syndrome types were yin deficiency and blood stasis,phlegm heat and blood stasis,and phlegm stasis intertwined.The deficiency syndrome elements were yin deficiency,yang deficiency,and qi deficiency,while the solid syndrome elements included blood stasis,phlegm,and heat(fire).The medication involved 104 ingredients,mainly including Rehmannia glutinosa,Salvia miltiorrhiza,scorpion and tangerine peel,which was subject to clinical differentiation for treatment.Conclusion:Professor Mao believes that patients with PVC often experience deficiency and blood stasis.The main idea of its treatment is to nourish yin and quench wind,dissipate blood stasis and unblock collaterals.The core prescriptions for clinical treatment of PVC include Rehmannia glutinosa,Salvia miltiorrhiza,scorpion and tangerine peel,and medication should based on specific syndrome differentiation.

关 键 词：室性期前收缩 用药特点 数据挖掘 毛静远 

分 类 号：R259[医药卫生—中西医结合] R249[医药卫生—中医内科学]