复方丹参注射液联合常规降压药物治疗妊娠期高血压疗效的Meta分析  

Meta-analysis of Compound Salvia Miltiorrhiza Injection Combined with Conventional Antihypertensive Drugs for the Treatment of Gestational Hypertension

作　　者：黄瑶 王金权 付静娅 HUANG Yao;WANG Jinquan;FU Jinya(Shanxi University of Chinese Medicine,Taiyuan 030619,Shanxi,China;Shaanxi University of Chinese Medicine,Xianyang 712000,Shaanxi,China)

机构地区：[1]山西中医药大学,太原030619 [2]陕西中医药大学,陕西咸阳712000

出　　处：《中西医结合心脑血管病杂志》2024年第20期3682-3688,共7页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

基　　金：全国中医流派传承工作室建设项目三晋王氏中医妇科流派传承工作室(No.LP0104007);山西省2020年建设中医药强省补助资金王金权省级名中医传承工作室建设项目。

摘　　要：目的:评价复方丹参注射液或丹参注射液联合常规降压药治疗妊娠期高血压病人的安全性及对妊娠结局的影响。方法:计算机检索中英文数据库,包括万方数据库、中国知网(CNKI)、维普、中国生物医学文献数据库、PubMed、EMbase、the Cochrane Library等数据库。筛选整理复方丹参注射液或丹参注射液联合降压药治疗妊娠期高血压的随机对照试验(RCT),对筛选的文献进行整理后采用RevMan 5.3.1软件进行Meta分析。结果:最终纳入13篇RCT,Meta分析结果显示,试验组临床疗效[RR=1.24,95%CI(1.17,1.31),P<0.00001]、收缩压[MD=-11.61,95%CI(-14.67,-8.56),P<0.00001]、舒张压[MD=-7.48,95%CI(-9.31,-5.56),P<0.00001]、胎儿窘迫发生率[RR=0.25,95%CI(0.15,0.43),P<0.00001]、产后出血发生率[RR=0.32,95%CI(0.20,0.51),P<0.00001]、剖宫产发生率[RR=0.56,95%CI(0.46,0.69),P<0.00001]、早产发生率[RR=0.44,95%CI(0.24,0.80),P=0.007]较对照组明显改善。结论:现有证据表明,丹参注射液可以辅助降压药物获得更理想的目标血压,提升治疗效果,降低不良妊娠结局发生率,安全性与有效性较好。Objective:To assess the safety of salvia miltiorrhiza injection-assisted antihypertensive drugs for treating gestational hypertension and its impact on pregnancy outcomes.Methods:Chinese and English databases,including WanFang Database,CNKI,VIP,PubMed,EMbase,and the Cochrane Library,etc were searched.Randomized controlled trials(RCTs)of salvia miltiorrhiza injection combined with antihypertensive drugs for the treatment of gestational hypertension were screened and sorted out.Meta-analysis was performed using RevMan 5.3.1 software.1.Results:A total of 13 RCTs were included.The results of the Meta-analysis showed that the clinical efficacy(RR=1.24,95%CI 1.17-1.31,P<0.00001),systolic blood pressure(MD=-11.61,95%CI-14.67--8.56,P<0.00001),diastolic blood pressure(MD=-7.48,95%CI-9.31--5.56,P<0.00001),fetal distress(RR=0.25,95%CI 0.15-0.43,P<0.00001),postpartum hemorrhage(RR=0.32,95%CI 0.20-0.51,P<0.00001),cesarean section rate(RR=0.56,95%CI 0.46-0.69,P<0.00001),preterm birth rate(RR=0.44,95%CI 0.24-0.80,P=0.007)in the experimental group were better than those in the control group.Conclusion:Salvia miltiorrhiza injection can assist antihypertensive drugs to obtain more ideal target blood pressure,improve the therapeutic effect,reduce the incidence of adverse pregnancy outcomes,and enhance the safety and effectiveness of clinical promotion.

关 键 词：妊娠期高血压 丹参注射液 降压药 妊娠结局 安全性 系统评价 

分 类 号：R714.246[医药卫生—妇产科学]